Title:
POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/057123
Kind Code:
A1
Abstract:
The present invention provides a polycyclic compound that acts as an IDO inhibitor and/or an IDO-HDAC dual inhibitor. Specifically, the present invention provides a compound represented by the following formula (I), the definition of each group being as described in description. The compound has IDO inhibitory activities or IDO-HDAC dual inhibitory activities, and can be used for preventing or treating diseases associated with IDO and/or IDO-HDAC activity or expression level. In addition, the compound of the present invention can be administered in combination with anti-tumor immune antibodies such as PD-1 and PD-L1, so as to greatly improve the anti-tumor response rate of the antibody and broaden the range of treatable tumor types. (I)
Inventors:
ZHANG HANCHENG (CN)
YE XIANGYANG (CN)
YE XIANGYANG (CN)
Application Number:
PCT/CN2018/106768
Publication Date:
March 28, 2019
Filing Date:
September 20, 2018
Export Citation:
Assignee:
HANGZHOU INNOGATE PHARMA CO LTD (CN)
International Classes:
C07D403/00; A61K31/44; A61K31/47; C07D209/00; C07D209/02; C07D215/02; C07D215/04; C07D215/06; C07D401/00; C07D401/02; C07D403/02
Domestic Patent References:
| WO2015188085A1 | 2015-12-10 | |||
| WO2016073738A2 | 2016-05-12 | |||
| WO2016073770A1 | 2016-05-12 | |||
| WO2016073774A2 | 2016-05-12 | |||
| WO2017192840A1 | 2017-11-09 | |||
| WO2017192844A1 | 2017-11-09 | |||
| WO2017192845A1 | 2017-11-09 | |||
| WO2017001928A1 | 2017-01-05 | |||
| WO2017024996A1 | 2017-02-16 |
Foreign References:
| US20090192141A1 | 2009-07-30 | |||
| CN106916164A | 2017-07-04 |
Other References:
TOPCZEWSKI, J.J. ET AL.: "Palladium-Catalysed Transannular C-H Functionalization of Alicyclic Amines", NATURE, vol. 531, no. 7593, 10 March 2016 (2016-03-10), pages 220 - 224, XP055584145
See also references of EP 3686196A4
See also references of EP 3686196A4
Attorney, Agent or Firm:
XU AND PARTNERS, LLC. (CN)
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