Title:
POLYCYCLIC COMPOUND FOR INHIBITING RNA HELICASE DHX33, AND APPLICATION OF COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/274251
Kind Code:
A1
Abstract:
The present invention relates to a polycyclic compound for inhibiting RNA helicase DHX33, and an application of the compound. In particular, the present invention relates to a compound as represented by formula I or a pharmaceutically acceptable form thereof, a pharmaceutical composition comprising same, a preparation method therefor, and a medical use thereof for preventing and/or treating DHX33-associated diseases.
Inventors:
ZHANG YANDONG (CN)
LI XIANGLU (CN)
LI XIANGLU (CN)
Application Number:
PCT/CN2022/102010
Publication Date:
January 05, 2023
Filing Date:
June 28, 2022
Export Citation:
Assignee:
SHENZHEN KEYE LIFE TECH CO LTD (CN)
International Classes:
C07D409/14; A61K31/4184; A61K31/422; A61K31/427; A61K31/437; A61K31/4439; A61K31/506; A61P29/00; A61P31/14; A61P35/00; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D413/14; C07D417/14; C07D471/04
Domestic Patent References:
| WO2022127199A1 | 2022-06-23 |
Foreign References:
| CN101006052A | 2007-07-25 | |||
| CN112661754A | 2021-04-16 | |||
| CN112585119A | 2021-03-30 |
Other References:
DATABASE REGISTRY 12 August 2012 (2012-08-12), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-1-(2,3-dihydro-1,4- benzodioxin-6-yl)-2,5-dimethyl-(CA INDEX NAME)", XP093019001, retrieved from STN Database accession no. 1388909-96-3
DATABASE REGISTRY 12 August 2012 (2012-08-12), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-2,5-dimethyl-1-(3- pyridinyl)-(CA INDEX NAME)", XP093019005, retrieved from STN Database accession no. 1388933-27-4
DATABASE REGISTRY 2 May 2017 (2017-05-02), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-2,5-dimethyl-1-(4- pyridinylmethyl)-(CA INDEX NAME)", XP093019007, retrieved from STN Database accession no. 2094154-59-1
DATABASE REGISTRY 27 February 2018 (2018-02-27), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-2,5-dimethyl-1-(2- thienylmethyl)-(CA INDEX NAME)", XP093019010, retrieved from STN Database accession no. 2180556-14-1
DATABASE REGISTRY 27 February 2018 (2018-02-27), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-1-(2-furanylmethyl)-2,5- dimethyl-(CA INDEX NAME) ", XP093019011, retrieved from STN Database accession no. 2180631-72-3
JUSIAK, SOCZEWINSKI ET AL.: "Remington's Pharmaceutical Sciences", 2005, MACK PUBLISHING COMPANY
STAHL, WERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use [M", 2002, WILEY-VCH
GOODMANGILMAN'S: "The Pharmacological Basis of Therapeutics", 1996, MCGRAW-HILL
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Drug Delivery Systems [J", vol. 14, 1975, AMERICAN CHEMICAL SOCIETY
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis [M", 2006, JOHN WILEY & SONS
WANG XGE WZHANG Y: "Recombinant DHX33 Protein Possesses Dual DNA/RNA Helicase Activity", BIOCHEMISTRY, vol. 58, no. 4, 2019, pages 250 - 8
DATABASE REGISTRY 12 August 2012 (2012-08-12), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-2,5-dimethyl-1-(3- pyridinyl)-(CA INDEX NAME)", XP093019005, retrieved from STN Database accession no. 1388933-27-4
DATABASE REGISTRY 2 May 2017 (2017-05-02), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-2,5-dimethyl-1-(4- pyridinylmethyl)-(CA INDEX NAME)", XP093019007, retrieved from STN Database accession no. 2094154-59-1
DATABASE REGISTRY 27 February 2018 (2018-02-27), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-2,5-dimethyl-1-(2- thienylmethyl)-(CA INDEX NAME)", XP093019010, retrieved from STN Database accession no. 2180556-14-1
DATABASE REGISTRY 27 February 2018 (2018-02-27), ANONYMOUS : "-1H-Pyrrole-3-carboxamide, N-1H-benzimidazol-2-yl-1-(2-furanylmethyl)-2,5- dimethyl-(CA INDEX NAME) ", XP093019011, retrieved from STN Database accession no. 2180631-72-3
JUSIAK, SOCZEWINSKI ET AL.: "Remington's Pharmaceutical Sciences", 2005, MACK PUBLISHING COMPANY
STAHL, WERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use [M", 2002, WILEY-VCH
GOODMANGILMAN'S: "The Pharmacological Basis of Therapeutics", 1996, MCGRAW-HILL
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Drug Delivery Systems [J", vol. 14, 1975, AMERICAN CHEMICAL SOCIETY
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis [M", 2006, JOHN WILEY & SONS
WANG XGE WZHANG Y: "Recombinant DHX33 Protein Possesses Dual DNA/RNA Helicase Activity", BIOCHEMISTRY, vol. 58, no. 4, 2019, pages 250 - 8
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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