Title:
POLYENE POLYKETIDES AND METHODS OF PRODUCTION
Document Type and Number:
WIPO Patent Application WO2005024025
Kind Code:
A8
Abstract:
Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. Formula (I) One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC(TM) 43491 or a mutant or variant such as the strain IDAC-220604-1. Another method for obtaining the compounds is post-biosynthesis chemical modification of the compounds obtained by cultivation. Novel polynucleotide sequences and encoded proteins for the biosynthesis of the polyene polyketides are also presented.
Inventors:
MCALPINE JAMES B (CA)
FARNET CHRIS M (CA)
ZAZOPOULOS EMMANUEL (CA)
SORENSEN DAN (CA)
FARNET CHRIS M (CA)
ZAZOPOULOS EMMANUEL (CA)
SORENSEN DAN (CA)
Application Number:
PCT/CA2004/001603
Publication Date:
May 19, 2005
Filing Date:
September 10, 2004
Export Citation:
Assignee:
MCALPINE JAMES B (CA)
FARNET CHRIS M (CA)
ZAZOPOULOS EMMANUEL (CA)
SORENSEN DAN (CA)
ECOPIA BIOSCIENCES INC (CA)
FARNET CHRIS M (CA)
ZAZOPOULOS EMMANUEL (CA)
SORENSEN DAN (CA)
ECOPIA BIOSCIENCES INC (CA)
International Classes:
A61K31/513; A61K31/70; A61K31/704; A61P31/04; C07C279/14; C07D309/10; C07H5/04; C07H5/06; C12N15/31; C12N15/52; C12P7/42; C12P7/64; C12P13/00; C12P17/06; C12P17/16; C12P19/44; (IPC1-7): C12N15/52; A61K31/35; A61P31/04; C07D309/10; C07D493/04; C07K14/195; C12N1/20; C12N9/00; C12N15/31; C12N15/63; C12P1/04; C12P17/06; C12P17/16; C12P21/02
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