Title:
POLYETHYLENE GLYCOL MODIFIED INTERFERON COMPOSITIONS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2004076474
Kind Code:
A3
Abstract:
Interferon alpha (IFN-alpha) linked to a linear polyethylene glycol (PEG) molecule having a nominal molecular weight of about 30 kD, and compositions comprising the same, are provided. The invention further provides methods of treating a viral infection with the subject PEG-modified IFN-alpha.
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Inventors:
VAN VLASSELAER PETER (US)
ROBERTS MICHAEL J (US)
VISOR GARY (US)
CHARLES STEPHEN A (US)
ROBERTS MICHAEL J (US)
VISOR GARY (US)
CHARLES STEPHEN A (US)
Application Number:
PCT/US2004/005649
Publication Date:
January 06, 2005
Filing Date:
February 24, 2004
Export Citation:
Assignee:
INTERMUNE INC (US)
VAN VLASSELAER PETER (US)
ROBERTS MICHAEL J (US)
VISOR GARY (US)
CHARLES STEPHEN A (US)
VAN VLASSELAER PETER (US)
ROBERTS MICHAEL J (US)
VISOR GARY (US)
CHARLES STEPHEN A (US)
International Classes:
A61K47/48; C07K1/107; C07K1/113; C07K14/56; A61K38/00; C07K; (IPC1-7): C07K14/56; A61K47/48; C07K1/107; C07K1/113
Foreign References:
| US5382657A | 1995-01-17 | |||
| US20030055013A1 | 2003-03-20 | |||
| US5981709A | 1999-11-09 | |||
| EP0822199A2 | 1998-02-04 |
Other References:
MONKARSH S ET AL: "Positional Isomers of Monopegylated Interferon alpha-2a: Isolation, Characterization, and Biological Activity", ANALYTICAL BIOCHEMISTRY, vol. 247, 1997, pages 434 - 440, XP002092303
FOSER S ET AL: "Isolation, structural characterization, and antiviral activity of positional isomers of monopegylated interferon alpha-2a", PROTEIN EXPRESSION PURIFICATION, vol. 30, July 2003 (2003-07-01), pages 78 - 87, XP004432807
KOZLOWSKI A ET AL: "Development of Pegylated Interferons for the Treatment of Chronic Hepatitis C", BIODRUGS, vol. 15, no. 7, 2001, pages 419 - 429, XP002903517
See also references of EP 1597278A4
FOSER S ET AL: "Isolation, structural characterization, and antiviral activity of positional isomers of monopegylated interferon alpha-2a", PROTEIN EXPRESSION PURIFICATION, vol. 30, July 2003 (2003-07-01), pages 78 - 87, XP004432807
KOZLOWSKI A ET AL: "Development of Pegylated Interferons for the Treatment of Chronic Hepatitis C", BIODRUGS, vol. 15, no. 7, 2001, pages 419 - 429, XP002903517
See also references of EP 1597278A4
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