Title:
POLYLYSINE SALT, PREPARATION METHOD THEREFOR, AND PURIFICATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/221978
Kind Code:
A1
Abstract:
Provided are a polylysine salt and a purification method therefor. The purification method for the polylysine salt comprises: providing a crude product to be purified, the crude product to be purified comprising at least one among a crude product of a polylysine salt, a polylysine trifluoroacetate salt, a polylysine salt that combines three or two acetic acids, a polylysine salt that combines three or two hydrochloric acids; mixing a mixed solution of the crude product to be purified and a solvent with a strongly alkaline anion exchange resin, and separating a filtrate; adding an acidic solvent into the filtrate, performing salt conversion, and removing the solvent to obtain the polylysine salt.
Inventors:
TAO XIUMEI (CN)
GAO HONGWEI (CN)
QIN YUANMAN (CN)
GAO QIFU (CN)
MA JIANJIA (CN)
GAO HONGWEI (CN)
QIN YUANMAN (CN)
GAO QIFU (CN)
MA JIANJIA (CN)
Application Number:
PCT/CN2023/094530
Publication Date:
November 23, 2023
Filing Date:
May 16, 2023
Export Citation:
Assignee:
NKD PHARM CO LTD (CN)
International Classes:
A61K47/18; A61K47/34; C08J3/075
Domestic Patent References:
| WO2018233591A1 | 2018-12-27 | |||
| WO2021253305A1 | 2021-12-23 |
Foreign References:
| CN113171463A | 2021-07-27 | |||
| CN102911493A | 2013-02-06 | |||
| CN105778124A | 2016-07-20 | |||
| CN109077993A | 2018-12-25 | |||
| CN112028784A | 2020-12-04 |
Other References:
LIU SA, HONGXIA DONG, JIANWEI GUO: "Synthesis and Characterization of Poly-L-Lysine Dendrimers", POLYMER MATERIALS SCIENCE & ENGINEERING, vol. 27, no. 5, 15 August 2011 (2011-08-15), pages 20 - 23, XP093108185
VERBARO DANIEL J., MATHIEU DANIEL, TOAL SIOBHAN E., SCHWALBE HARALD, SCHWEITZER-STENNER REINHARD: "Ionized trilysine: a model system for understanding the nonrandom structure of poly-L-lysine and lysine-containing motifs in proteins", JOURNAL OF PHYSICAL CHEMISTRY PART B, AMERICAN CHEMICAL SOCIETY, US, vol. 116, no. 28, 19 July 2012 (2012-07-19), US , pages 8084 - 8094, XP093108186, ISSN: 1520-6106, DOI: 10.1021/jp303794s
VERBARO DANIEL J., MATHIEU DANIEL, TOAL SIOBHAN E., SCHWALBE HARALD, SCHWEITZER-STENNER REINHARD: "Ionized trilysine: a model system for understanding the nonrandom structure of poly-L-lysine and lysine-containing motifs in proteins", JOURNAL OF PHYSICAL CHEMISTRY PART B, AMERICAN CHEMICAL SOCIETY, US, vol. 116, no. 28, 19 July 2012 (2012-07-19), US , pages 8084 - 8094, XP093108186, ISSN: 1520-6106, DOI: 10.1021/jp303794s
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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