Title:
POLYMER AND COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/228555
Kind Code:
A1
Abstract:
The present application relates to a polymer and a composition thereof, and specifically provides a thermosensitive polymer represented by formula (I-2) and a preparation method therefor, and a pharmaceutical composition containing same, the polymer having a star-shaped multi-arm structure, and comprising an aromatic core and a biodegradable AB-type amphiphilic copolymer. The polymer can enhance the solubility and stability of a drug or a bioactive agent and control the release of the drug or the bioactive agent. The definition of each group in formula (I-2) is the same as in the description.
Inventors:
QU XIMING (CN)
WU FAN (CN)
FENG LEI (CN)
HUANG PENG (CN)
HUANG JIAN (CN)
WU FAN (CN)
FENG LEI (CN)
HUANG PENG (CN)
HUANG JIAN (CN)
Application Number:
PCT/CN2022/090327
Publication Date:
November 03, 2022
Filing Date:
April 29, 2022
Export Citation:
Assignee:
SHANGHAI SENHUI MEDICINE CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K9/00; C08F293/00
Foreign References:
| CN101845120A | 2010-09-29 | |||
| CN107929231A | 2018-04-20 | |||
| EP1988108A1 | 2008-11-05 | |||
| CN202110479406A | 2021-04-30 | |||
| CN202111188454A | 2021-10-12 |
Other References:
DHAWAL D. ANKOLA, M. N. V. RAVI KUMAR, FEDERICA CHIELLINI, ROBERTO SOLARO: "Multiblock Copolymers of Lactic Acid and Ethylene Glycol Containing Periodic Side-Chain Carboxyl Groups: Synthesis, Characterization, and Nanoparticle Preparation", MACROMOLECULES, vol. 42, no. 19, 13 October 2009 (2009-10-13), pages 7388 - 7395, XP055064741, ISSN: 0024-9297, DOI: 10.1021/ma9012253
GANUGULA RAGHU, ARORA MEENAKSHI, SAINI PRABHJOT, GUADA MELISSA, KUMAR MAJETI N. V. RAVI: "Next Generation Precision-Polyesters Enabling Optimization of Ligand–Receptor Stoichiometry for Modular Drug Delivery", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 21, 31 May 2017 (2017-05-31), pages 7203 - 7216, XP055981257, ISSN: 0002-7863, DOI: 10.1021/jacs.6b13231
"Biodegradable block copolymers as injectable drug-delivery systems", NATURE, vol. 388, no. 6645, 28 August 1997 (1997-08-28), pages 860 - 2
GANUGULA RAGHU, ARORA MEENAKSHI, SAINI PRABHJOT, GUADA MELISSA, KUMAR MAJETI N. V. RAVI: "Next Generation Precision-Polyesters Enabling Optimization of Ligand–Receptor Stoichiometry for Modular Drug Delivery", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 21, 31 May 2017 (2017-05-31), pages 7203 - 7216, XP055981257, ISSN: 0002-7863, DOI: 10.1021/jacs.6b13231
"Biodegradable block copolymers as injectable drug-delivery systems", NATURE, vol. 388, no. 6645, 28 August 1997 (1997-08-28), pages 860 - 2
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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