Title:
POLYPEPTIDE, DERIVATIVE THEREOF, HYDROGEL, AND APPLICATION THEREOF IN PREPARING DRUG FOR PREVENTING AND/OR TREATING TYPE I DIABETES
Document Type and Number:
WIPO Patent Application WO/2022/099991
Kind Code:
A1
Abstract:
The present invention belongs to the field of medicine and pharmacy, and provides a polypeptide, a derivative thereof, a hydrogel, and an application in preparing a drug for preventing and/or treating type I diabetes. The present invention provides a polypeptide whose sequence is shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, and a derivative of the polypeptide and a hydrogel thereof. The polypeptide, the derivative thereof and the hydrogel preparation process of the present invention are simple, the chemical structure of the product is clear, the raw materials used are amino acids daily required for the human body, the costs are low, and biocompatibility is good. The polypeptide, the derivative thereof and the hydrogel are capable of mimicking insulin epitopes, can restore immune tolerance to insulin antigens, have high ability to clear blood sugar and keep blood sugar stable within a normal range, and can effectively reduce the incidence of type 1 diabetes.
Inventors:
YANG ZHIMOU (CN)
WANG LING (CN)
WANG ZHONGYAN (CN)
LI CHEN (CN)
LIU MOHAN (CN)
WANG LING (CN)
WANG ZHONGYAN (CN)
LI CHEN (CN)
LIU MOHAN (CN)
Application Number:
PCT/CN2021/086779
Publication Date:
May 19, 2022
Filing Date:
April 13, 2021
Export Citation:
Assignee:
UNIV NANKAI (CN)
INST BIOMEDICAL ENG CAMS (CN)
INST BIOMEDICAL ENG CAMS (CN)
International Classes:
A61K39/00; C07K5/103; A61P3/10; C07K5/065; C08J3/075; C08L89/00
Foreign References:
| CN112358529A | 2021-02-12 | |||
| CN106008667A | 2016-10-12 | |||
| CN107522772A | 2017-12-29 | |||
| EP3502248A1 | 2019-06-26 |
Other References:
YANG, JINGYI: " Research on Treatments of Type 1 Diabetes", MEDICINE & PUBLIC HEALTH, CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES FULL-TEXT DATABASES, 1 May 2019 (2019-05-01), pages 1 - 64, XP055930665, [retrieved on 20220613], DOI: 10.1051/0004-6361/201220574
ZHAO, JUN: " Preparation of Fmoc-diphenylalanine gels and their applications", CHINESE MASTER’S THESES FULL-TEXT DATABASE, ENGINEERING SCIENCE AND TECHNOLOGY I, 1 June 2014 (2014-06-01), pages 1 - 75, XP055930675
LUO ZICHAO, WU QINJIE, YANG CHENGBIAO, WANG HUAIMIN, HE TAO, WANG YOUZHI, WANG ZHONGYAN, CHEN HAO, LI XINGYI, GONG CHANGYANG, YANG: "A Powerful CD8 + T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 29, no. 5, 1 February 2017 (2017-02-01), DE , pages 1601776, XP055930681, ISSN: 0935-9648, DOI: 10.1002/adma.201601776
INOUYE KEN, WATANABE KUNIO, TOCHINO YOSHIHIRO, KOBAYASHI MASASHI, SHIGETA YUKIO: "Semisynthesis and properties of some insulin analogs", BIOPOLYMERS, JOHN WILEY, HOBOKEN, USA, vol. 20, no. 9, 1 September 1981 (1981-09-01), Hoboken, USA, pages 1845 - 1858, XP055930686, ISSN: 0006-3525, DOI: 10.1002/bip.1981.360200909
ZHAO, JUN: " Preparation of Fmoc-diphenylalanine gels and their applications", CHINESE MASTER’S THESES FULL-TEXT DATABASE, ENGINEERING SCIENCE AND TECHNOLOGY I, 1 June 2014 (2014-06-01), pages 1 - 75, XP055930675
LUO ZICHAO, WU QINJIE, YANG CHENGBIAO, WANG HUAIMIN, HE TAO, WANG YOUZHI, WANG ZHONGYAN, CHEN HAO, LI XINGYI, GONG CHANGYANG, YANG: "A Powerful CD8 + T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 29, no. 5, 1 February 2017 (2017-02-01), DE , pages 1601776, XP055930681, ISSN: 0935-9648, DOI: 10.1002/adma.201601776
INOUYE KEN, WATANABE KUNIO, TOCHINO YOSHIHIRO, KOBAYASHI MASASHI, SHIGETA YUKIO: "Semisynthesis and properties of some insulin analogs", BIOPOLYMERS, JOHN WILEY, HOBOKEN, USA, vol. 20, no. 9, 1 September 1981 (1981-09-01), Hoboken, USA, pages 1845 - 1858, XP055930686, ISSN: 0006-3525, DOI: 10.1002/bip.1981.360200909
Attorney, Agent or Firm:
RZBC PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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