Title:
POLYPEPTIDES CAPABLE OF INTERACTING WITH SMAD POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO2002070702
Kind Code:
A3
Abstract:
A polypeptide (interacting polypeptide) capable of interacting with a Smad polypeptide wherein the interacting polypeptide comprises the amino acid sequence LPTSY and/or PNXXXP(P/L) or PN(V/A)V(A/M)P(P/L) and is less than 84 amino acids in length or is not full-length Xenopus or human FAST1 or a fragment thereof, mouse FAST2, Xenopus FAST3 or Zebrafish Fast 1. The Smad polypeptide may be Smad2 or Smad3 or Smad4. The interacting polypeptides are useful in screening assays and in medicine.
Inventors:
HILL CAROLINE (GB)
RANDALL REBECCA (GB)
HOWELL MICHAEL (GB)
RANDALL REBECCA (GB)
HOWELL MICHAEL (GB)
Application Number:
PCT/GB2002/000877
Publication Date:
March 13, 2003
Filing Date:
February 28, 2002
Export Citation:
Assignee:
CANCER REC TECH LTD (GB)
HILL CAROLINE (GB)
RANDALL REBECCA (GB)
HOWELL MICHAEL (GB)
HILL CAROLINE (GB)
RANDALL REBECCA (GB)
HOWELL MICHAEL (GB)
International Classes:
C07K14/47; C12N15/12; (IPC1-7): C12N15/12; A61K38/17; C07K14/47; C07K16/18
Domestic Patent References:
| WO1998053830A1 | 1998-12-03 | |||
| WO2000002910A2 | 2000-01-20 | |||
| WO2001014413A2 | 2001-03-01 |
Other References:
GERMAIN S ET AL: "Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 14, no. 4, April 2000 (2000-04-01), pages 435 - 451, XP002161544, ISSN: 0890-9369
ZHOU S ET AL: "CHARACTERIZATION OF HUMAN FAST-1, A TGFBETA AND ACTIVIN SIGNAL TRANSDUCER", MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 2, no. 1, July 1998 (1998-07-01), pages 121 - 127, XP000857313, ISSN: 1097-2765
WEISBERG E ET AL: "A MOUSE HOMOLOGUE OF FAST-1 TRANSDUCES TGFBETA SUPERFAMILY SIGNALS AND IS EXPRESSED DURING EARLY EMBRYOGENESIS", MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE IRELAND LTD, IE, vol. 79, no. 1/2, 1998, pages 17 - 27, XP000862876, ISSN: 0925-4773
BOGGETTI, B. ET AL: "Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer ( FAST ), a transcription factor mediating Nodal-related signals", MECHANISMS OF DEVELOPMENT (2000), 99(1,2), 187-190, 2000, XP002223320
CHEN X ET AL: "A TRANSCRIPTIONAL PARTNER FOR MAD PROTEINS IN TGF-BETA SIGNALLING", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 383, no. 6602, 24 October 1996 (1996-10-24), pages 691 - 696, XP002047848, ISSN: 0028-0836
DEROSSI D (REPRINT) ET AL: "Trojan peptides: the penetratin system for intracellular delivery", TRENDS IN CELL BIOLOGY, ELSEVIER SCIENCE LTD, XX, vol. 8, no. 2, February 1998 (1998-02-01), pages 84 - 87, XP002122131, ISSN: 0962-8924
ZHOU S ET AL: "CHARACTERIZATION OF HUMAN FAST-1, A TGFBETA AND ACTIVIN SIGNAL TRANSDUCER", MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 2, no. 1, July 1998 (1998-07-01), pages 121 - 127, XP000857313, ISSN: 1097-2765
WEISBERG E ET AL: "A MOUSE HOMOLOGUE OF FAST-1 TRANSDUCES TGFBETA SUPERFAMILY SIGNALS AND IS EXPRESSED DURING EARLY EMBRYOGENESIS", MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE IRELAND LTD, IE, vol. 79, no. 1/2, 1998, pages 17 - 27, XP000862876, ISSN: 0925-4773
BOGGETTI, B. ET AL: "Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer ( FAST ), a transcription factor mediating Nodal-related signals", MECHANISMS OF DEVELOPMENT (2000), 99(1,2), 187-190, 2000, XP002223320
CHEN X ET AL: "A TRANSCRIPTIONAL PARTNER FOR MAD PROTEINS IN TGF-BETA SIGNALLING", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 383, no. 6602, 24 October 1996 (1996-10-24), pages 691 - 696, XP002047848, ISSN: 0028-0836
DEROSSI D (REPRINT) ET AL: "Trojan peptides: the penetratin system for intracellular delivery", TRENDS IN CELL BIOLOGY, ELSEVIER SCIENCE LTD, XX, vol. 8, no. 2, February 1998 (1998-02-01), pages 84 - 87, XP002122131, ISSN: 0962-8924
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