Title:
POROUS INORGANIC CARRIER AND METHOD FOR PRODUCING NUCLEIC ACID USING SAME
Document Type and Number:
WIPO Patent Application WO/2020/202951
Kind Code:
A1
Abstract:
The present invention provides a porous inorganic carrier that further increases the purity of nucleic acid during production thereof. The porous inorganic carrier comprises a linker represented by general formula (1) (wherein the bond marked with the * represents a bond to the oxygen atom of a silanol group in the porous inorganic body; n represents an integer, e.g., 1; each R independently represents a C3-10 alkyl group optionally having a substituent, e.g., an alkoxy group; and L represents a single bond, a C1-20 alkylene group, or a C2-20 alkylene group that contains the group: -CH2-Q-CH2- as provided by the insertion of any group Q selected from the group consisting of -O- and so forth, in at least one -CH2-CH2- group present in said alkylene group), has a mode diameter of 0.04 μm to 1 μm, in the pore distribution measured by a mercury intrusion method, and has a predetermined cumulative pore volume percentage of not more than 30%. The present invention also provides a method for producing a nucleic acid using the porous inorganic carrier.
Inventors:
KITAHARA MASAKI (JP)
YOSHIOKA TAKESHI (JP)
HARA TAKASHI (JP)
ARIMURA TAKASHI (JP)
ISHIYAMA TAKESHI (JP)
KISHIDA HIROSHI (JP)
YOSHIOKA TAKESHI (JP)
HARA TAKASHI (JP)
ARIMURA TAKASHI (JP)
ISHIYAMA TAKESHI (JP)
KISHIDA HIROSHI (JP)
Application Number:
PCT/JP2020/008321
Publication Date:
October 08, 2020
Filing Date:
February 28, 2020
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
B01J31/26; B01J32/00; C01B33/12; C01B39/36; C07F7/18; C07H21/04; C12N15/10
Domestic Patent References:
| WO2013062105A1 | 2013-05-02 | |||
| WO2013027843A1 | 2013-02-28 | |||
| WO2012017919A1 | 2012-02-09 | |||
| WO2013103146A1 | 2013-07-11 | |||
| WO2017188042A1 | 2017-11-02 |
Foreign References:
| CN108176387A | 2018-06-19 | |||
| JP2011088843A | 2011-05-06 | |||
| JP2006502856A | 2006-01-26 | |||
| JP2019067995A | 2019-04-25 | |||
| US20090005536A1 | 2009-01-01 | |||
| US3687808A | 1972-08-29 | |||
| JP5875843B2 | 2016-03-02 | |||
| JP2010120780A | 2010-06-03 | |||
| US20120035246A1 | 2012-02-09 |
Other References:
TOSOH RESEARCH TECHNOLOGY REVIEW, vol. 45, 2001
A.P. GUZAEVM. MANOHARAN, J AMCHEM SOC, vol. 125, 2003, pages 2380 - 2381
R.K. KUMARA.P. GUZAEVC. RENTELV.T. RAVIKUMAR, TETRAHEDRON, vol. 62, 2006, pages 4528
"Concise Encyclopedia Of Polymer Science And Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL.: "Angewandte Chemie", vol. 30, 1991, pages: 613
CHAKHMAKHCHEVA: "Protective Groups in the Chemical Synthesis of Oligoribonucleotides", RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol. 39, no. 1, 2013, pages 1 - 21, XP035369459, DOI: 10.1134/S1068162013010020
CAS , no. 919-30-2
See also references of EP 3950125A4
A.P. GUZAEVM. MANOHARAN, J AMCHEM SOC, vol. 125, 2003, pages 2380 - 2381
R.K. KUMARA.P. GUZAEVC. RENTELV.T. RAVIKUMAR, TETRAHEDRON, vol. 62, 2006, pages 4528
"Concise Encyclopedia Of Polymer Science And Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL.: "Angewandte Chemie", vol. 30, 1991, pages: 613
CHAKHMAKHCHEVA: "Protective Groups in the Chemical Synthesis of Oligoribonucleotides", RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol. 39, no. 1, 2013, pages 1 - 21, XP035369459, DOI: 10.1134/S1068162013010020
CAS , no. 919-30-2
See also references of EP 3950125A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
Download PDF: