POSITIVE ALLOSTERIC MODULATORS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR

Title:

POSITIVE ALLOSTERIC MODULATORS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR

Document Type and Number:

WIPO Patent Application WO2003093250

Kind Code:

A3

Abstract:

The invention provides compounds of Formula I: (1) these compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which alpha7 nAChR is known to be involved.

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Inventors:

PIOTROWSKI DAVID W (US)
ROGERS BRUCE N (US)
MCWHORTER WILLIAM W JR (US)
WALKER DANIEL P (US)
CORBETT JEFFREY W (US)
GROPPI VINCENT E JR (US)
RUDMANN DANIEL G (US)

Application Number:

PCT/US2003/011493

Publication Date:

December 23, 2004

Filing Date:

April 28, 2003

Export Citation:

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Assignee:

UPJOHN CO (US)
PIOTROWSKI DAVID W (US)
ROGERS BRUCE N (US)
MCWHORTER WILLIAM W JR (US)
WALKER DANIEL P (US)
CORBETT JEFFREY W (US)
GROPPI VINCENT E JR (US)
RUDMANN DANIEL G (US)

International Classes:

C07C275/34; C07C275/40; C07C323/44; C07C335/18; C07D213/75; C07D231/16; C07D231/40; C07D233/88; C07D261/14; C07D277/48; C07D277/56; C07D277/82; C07D285/135; C07D413/12; C07D417/12; C07D285/12; (IPC1-7): C07C275/34; A61K31/17; A61K31/395; C07C275/40; C07C335/18; C07D233/88; C07D261/14; C07D277/48; C07D285/12; C07D413/12; C07D417/12

Domestic Patent References:

WO2002002071A2	2002-01-10
WO2000026203A1	2000-05-11
WO1994022807A1	1994-10-13
WO1999000357A1	1999-01-07
WO1997045400A1	1997-12-04
WO2001068568A2	2001-09-20
WO1996025157A1	1996-08-22
WO2000035455A1	2000-06-22
WO2002020016A1	2002-03-14

Foreign References:

DE2436179A1	1975-02-06
US5814646A	1998-09-29
US3990879A	1976-11-09
US5162360A	1992-11-10
US5059614A	1991-10-22

Other References:

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