Title:
PREDICTION OF THE TREATMENT RESPONSE TO BUMETANIDE IN SUBJECT WITH AUTISM SPECTRUM DISORDER
Document Type and Number:
WIPO Patent Application WO/2023/198176
Kind Code:
A1
Abstract:
Provided is a method of predicting a response of a subject afflicted with an autism spectrum disorder (ASD) to bumetanide based on baseline expression levels of a set of cytokines in the subject, baseline behavioral performance of the subject and clinical information of the subject and the use thereof. Also provided are a prediction device and a computer readable medium for performing the prediction method.
Inventors:
LI FEI (CN)
Application Number:
PCT/CN2023/088307
Publication Date:
October 19, 2023
Filing Date:
April 14, 2023
Export Citation:
Assignee:
XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE (CN)
International Classes:
C12Q1/68; G01N33/48
Domestic Patent References:
| WO2014018774A1 | 2014-01-30 | |||
| WO2019086724A1 | 2019-05-09 |
Foreign References:
| US20140303031A1 | 2014-10-09 | |||
| US20190134011A1 | 2019-05-09 |
Other References:
LI QINGYANG, ZHANG LINGLI, SHAN HAIDI, YU JUEHUA, DAI YUAN, HE HUA, LI WEI-GUANG, LANGLEY CHRISTELLE, SAHAKIAN BARBARA J., YAO YIN: "The immuno-behavioural covariation associated with the treatment response to bumetanide in young children with autism spectrum disorder", TRANSLATIONAL PSYCHIATRY, vol. 12, no. 1, XP093098962, DOI: 10.1038/s41398-022-01987-x
EI-ANSARY, A. ET AL.: "GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders", JOURNAL OF NEUROINFLAMMATION, vol. 11, 19 November 2014 (2014-11-19), XP021204191, DOI: 10.1186/s12974-014-0189-0
ZHANG LINGLI, HUANG CHU-CHUNG, DAI YUAN, LUO QIANG, JI YITING, WANG KAI, DENG SHINING, YU JUEHUA, XU MINGYU, DU XIUJUAN, TANG YUN,: "Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios", TRANSLATIONAL PSYCHIATRY, vol. 10, no. 1, XP093098963, DOI: 10.1038/s41398-020-0692-2
DAI YUAN, ZHANG LINGLI, YU JUEHUA, ZHOU XIN, HE HUA, JI YITING, WANG KAI, DU XIUJUAN, LIU XIN, TANG YUN, DENG SHINING, LANGLEY CHR: "Improved symptoms following bumetanide treatment in children aged 3−6 years with autism spectrum disorder: a randomized, double-blind, placebo-controlled trial", SCIENCE BULLETIN, ZHONGGUO KEXUE ZAZHISHE, CN, vol. 66, no. 15, 1 August 2021 (2021-08-01), CN , pages 1591 - 1598, XP093098966, ISSN: 2095-9273, DOI: 10.1016/j.scib.2021.01.008
MASI, A. ET AL.: "The Immune System, Cytokines, and Biomarkers in Autism Spectrum Disorder", NEUROSCI. BULL., vol. 33, no. 2, 30 April 2017 (2017-04-30), pages 194 - 204, XP036195140, DOI: 10.1007/s12264-017-0103-8
HUNG, C.M. ET AL.: "Bumetanide attenuates acute lung injury by suppressing macrophage activation", BIOCHEMICAL PHARMACOLOGY, vol. 156, 11 August 2018 (2018-08-11), pages 60 - 67, XP085504079, DOI: 10.1016/j.bcp.2018.08.013
LI, X.H. ET AL.: "Elevated Immune Response in the Brain of Autistic Patients", J NEUROIMMUNOL., vol. 207, no. 1-2, 15 February 2009 (2009-02-15), pages 111 - 116, XP025994094, DOI: 10.1016/j.jneuroim.2008.12.002
MOLLAJANI RAHELEH, JOGHATAEI MOHAMAD TAGHI, TEHRANI-DOOST MEHDI: "Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study", BASIC AND CLINICAL NEUROSCIENCE JOURNAL, pages 433 - 442, XP093098971, ISSN: 2228-7442, DOI: 10.32598/bcn.9.10.380
EI-ANSARY, A. ET AL.: "GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders", JOURNAL OF NEUROINFLAMMATION, vol. 11, 19 November 2014 (2014-11-19), XP021204191, DOI: 10.1186/s12974-014-0189-0
ZHANG LINGLI, HUANG CHU-CHUNG, DAI YUAN, LUO QIANG, JI YITING, WANG KAI, DENG SHINING, YU JUEHUA, XU MINGYU, DU XIUJUAN, TANG YUN,: "Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios", TRANSLATIONAL PSYCHIATRY, vol. 10, no. 1, XP093098963, DOI: 10.1038/s41398-020-0692-2
DAI YUAN, ZHANG LINGLI, YU JUEHUA, ZHOU XIN, HE HUA, JI YITING, WANG KAI, DU XIUJUAN, LIU XIN, TANG YUN, DENG SHINING, LANGLEY CHR: "Improved symptoms following bumetanide treatment in children aged 3−6 years with autism spectrum disorder: a randomized, double-blind, placebo-controlled trial", SCIENCE BULLETIN, ZHONGGUO KEXUE ZAZHISHE, CN, vol. 66, no. 15, 1 August 2021 (2021-08-01), CN , pages 1591 - 1598, XP093098966, ISSN: 2095-9273, DOI: 10.1016/j.scib.2021.01.008
MASI, A. ET AL.: "The Immune System, Cytokines, and Biomarkers in Autism Spectrum Disorder", NEUROSCI. BULL., vol. 33, no. 2, 30 April 2017 (2017-04-30), pages 194 - 204, XP036195140, DOI: 10.1007/s12264-017-0103-8
HUNG, C.M. ET AL.: "Bumetanide attenuates acute lung injury by suppressing macrophage activation", BIOCHEMICAL PHARMACOLOGY, vol. 156, 11 August 2018 (2018-08-11), pages 60 - 67, XP085504079, DOI: 10.1016/j.bcp.2018.08.013
LI, X.H. ET AL.: "Elevated Immune Response in the Brain of Autistic Patients", J NEUROIMMUNOL., vol. 207, no. 1-2, 15 February 2009 (2009-02-15), pages 111 - 116, XP025994094, DOI: 10.1016/j.jneuroim.2008.12.002
MOLLAJANI RAHELEH, JOGHATAEI MOHAMAD TAGHI, TEHRANI-DOOST MEHDI: "Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study", BASIC AND CLINICAL NEUROSCIENCE JOURNAL, pages 433 - 442, XP093098971, ISSN: 2228-7442, DOI: 10.32598/bcn.9.10.380
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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