PREPARATION OF BIARYL RING-LINKED AROMATIC HETEROCYCLIC DERIVATIVE AS IMMUNOMODULATOR AND USE THEREOF - SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO LTD

Title:

PREPARATION OF BIARYL RING-LINKED AROMATIC HETEROCYCLIC DERIVATIVE AS IMMUNOMODULATOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/228000

Kind Code:

A1

Abstract:

The preparation of an aromatic heterocyclic derivative as an immunomodulator and the use thereof. Specifically, provided is a compound as represented by formula I below, or an optical isomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the definition of each group is as described in the description; and the compound of formula I can be used to treat diseases associated with the PD-1/PD-L1 signaling pathway.

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Inventors:

WANG ZHE (CN)
QIAN ANRAN (CN)
LI DELIANG (CN)

Application Number:

PCT/CN2021/092482

Publication Date:

November 18, 2021

Filing Date:

May 08, 2021

Export Citation:

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Assignee:

SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO LTD (CN)

International Classes:

C07D413/14; A61K31/33; A61P35/00; A61P37/00; C07D207/04; C07D471/04

Domestic Patent References:

WO2020011243A1	2020-01-16
WO2019192506A1	2019-10-10
WO2018195321A1	2018-10-25
WO2020086556A1	2020-04-30
WO2018195321A1	2018-10-25
WO2018005374A1	2018-01-04
WO2019023575A1	2019-01-31
WO2012158550A2	2012-11-22
WO2018119266A1	2018-06-28
WO2018119286A1	2018-06-28

Attorney, Agent or Firm:

XU&PARTNERS, LLC. (CN)

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