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Title:
PREPARATION METHOD FOR 3-CYANO-4-HYDROXYBENZOIC ACID METHYL ESTER
Document Type and Number:
WIPO Patent Application WO/2018/121050
Kind Code:
A1
Abstract:
Disclosed in the present invention is a preparation method for 3-cyano-4-hydroxybenzoic acid methyl ester, comprising: step 1: preparing methyl 4-hydroxybenzoate into methyl 3-formyl-4-hydroxybenzoate; and step 2: preparing the methyl 3-formyl-4-hydroxybenzoate into the 3-cyano-4-hydroxybenzoic acid methyl ester. The preparation method for the 3-cyano-4-hydroxybenzoic acid methyl ester of the present invention has the advantages of: (1) the use of toxic cyanide of cuprous cyanide in the previous processes is avoided and thus the method is more suitable for being used in industrial production; (2) a formyl group is prepared into a cyano group, thus having high efficiency, and thus the method is suitable for being used in mass production; and (3) all raw materials are cheap and easily available and thus the method has obvious cost advantage.

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Inventors:
CHI YONGGUI (CN)
HUANG XUAN (CN)
Application Number:
PCT/CN2017/109092
Publication Date:
July 05, 2018
Filing Date:
November 02, 2017
Export Citation:
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Assignee:
SUZHOU BLUEHILL BIOPHARMA CO LTD (CN)
International Classes:
C07C255/57; C07C253/00
Domestic Patent References:
WO2012154213A12012-11-15
Foreign References:
CN106674052A2017-05-17
CN106674044A2017-05-17
Other References:
HADA, K. ET AL.: "Angiogenesis Inhibitors Identified by Cell -based High-throughput Screening: Synthesis, Structure-activity Relationships and Biological Evaluation of 3-[(E)-styryl]benzamides that Specifically Inhibit Endothelial Cell Proliferation", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 4, 5 January 2012 (2012-01-05), pages 1442 - 1460, XP055482584, Retrieved from the Internet
WHITING, E. ET AL.: "Chromatography-Free Entry to Substituted Salicylonitriles: Mitsunobu-Triggered Domino Reactions of Salicylaldoximes", JOURNAL OF ORGANIC CHEMISTRY, vol. 80, no. 2, 24 December 2014 (2014-12-24), pages 1129 - 1234, XP055511306, Retrieved from the Internet
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