Title:
PREPARATION METHOD FOR METHYL 3-CYANO-4-ISOPROPOXYBENZOATE
Document Type and Number:
WIPO Patent Application WO/2018/121051
Kind Code:
A1
Abstract:
Disclosed is a preparation method for methyl 3-cyano-4-isopropoxybenzoate: step one, preparing methyl 3-aldehyde-4-hydroxybenzoate from methyl paraben; step two, preparing methyl 3-cyano-4-hydroxybenzonate from methyl 3-aldehyde-4-hydroxybenzonate; and step three, preparing methyl 3-cyano-4-isopropoxybenzoate from methyl 3-cyano-4-hydroxybenzonate. The preparation method for methyl 3-cyano-4-isopropoxybenzoate of the present invention provides the advantages that: 1) the use of copper cyanide, a toxic cyanide in the prior art, is avoided, thus being more suitable for industrialization; 2) a cyano group is prepared from an aldehyde group, thus being efficient, directly, and suitable for mass production; and 3) all raw materials are inexpensive and readily available, thus providing obvious cost advantage.
Inventors:
CHI YONGGUI (CN)
HUANG XUAN (CN)
HUANG XUAN (CN)
Application Number:
PCT/CN2017/109093
Publication Date:
July 05, 2018
Filing Date:
November 02, 2017
Export Citation:
Assignee:
SUZHOU BLUEHILL BIOPHARMA CO LTD (CN)
International Classes:
C07C255/57; C07C253/30
Domestic Patent References:
| WO2011072488A1 | 2011-06-23 | |||
| WO2016164180A1 | 2016-10-13 |
Foreign References:
| CN106674053A | 2017-05-17 | |||
| CN106674044A | 2017-05-17 | |||
| CN106674046A | 2017-05-17 |
Other References:
ZHU, YIZHONG: "Study on Cyanation of Aromatic Compounds and Its Application", SCIENCE -ENGINEERING (A), CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 28 February 2011 (2011-02-28), pages 18
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