Title:
PREPARATION METHOD FOR (3R,5R)-7-[2-(4-FLUROPHENYL)-5-ISOPROPYL-3-PHENYL-4-[(4-HYDROXYMETHYLPHENYLAMINO)CARBONYL]-PYRRROL-1-YL]-3,5-DIHYDROXY HEPTANOIC ACID HEMICALCIUM SALT, INTERMEDIATE USED THEREFOR, AND PREPARATION METHOD FOR INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2020/040614
Kind Code:
A1
Abstract:
The present invention provides: a preparation method for a (3R,5R)-7-[2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrrol-1-yl]-3,5-dihydroxy heptanoic acid hemicalcium salt; an intermediate used therefor; and a preparation method for the intermediate. The preparation method of the present invention is performed in a convergent synthesis manner in which main structure portions of the (3R,5R)-7-[2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrrol-1-yl]-3,5-dihydroxy heptanoic acid hemicalcium salt are separately synthesized, and then coupled. Therefore, related substances can be easily controlled and the preparation time can be shortened, leading to an improvement in productivity of compounds as well as an increase in yield of a final compound.
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Inventors:
PARK EUN-JUNG (KR)
LEE WON-IL (KR)
PARK SANG-WOOK (KR)
KIM BO-JUNG (KR)
JEONG SEO-HEE (KR)
KIM CHURL-WOO (KR)
SHIN SANG-YUN (KR)
CHO MIN-YONG (KR)
SOHN SE-IL (KR)
LEE WON-IL (KR)
PARK SANG-WOOK (KR)
KIM BO-JUNG (KR)
JEONG SEO-HEE (KR)
KIM CHURL-WOO (KR)
SHIN SANG-YUN (KR)
CHO MIN-YONG (KR)
SOHN SE-IL (KR)
Application Number:
PCT/KR2019/010799
Publication Date:
February 27, 2020
Filing Date:
August 23, 2019
Export Citation:
Assignee:
DAEWON PHARMACEUTICAL CO LTD (KR)
International Classes:
C07D207/337; C07C205/19; C07C213/02; C07C217/76; C07C231/02; C07C235/38
Domestic Patent References:
| WO2007054790A1 | 2007-05-18 |
Foreign References:
| CN106397296A | 2017-02-15 | |||
| KR20160117843A | 2016-10-11 | |||
| EP0247633A1 | 1987-12-02 | |||
| EP0680963A1 | 1995-11-08 |
Attorney, Agent or Firm:
AHN, So Young (KR)
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