Title:
PREPARATION METHOD FOR DIAZABICYCLO PEPTIDOMIMETIC DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246631
Kind Code:
A1
Abstract:
Disclosed are a preparation method for a diazabicyclo peptidomimetic derivative and use thereof. The preparation method comprises: using an intramolecular nucleophilic substitution reaction in which sulfonamide is taken as a nucleophilic reagent to synthesize an 8-membered ring in a ring-closing manner, and removing sulfonyl to synthesize a 1,5-diazabicyclo[6,3,0]undecanone amino acid derivative. The derivative prepared by the preparation method of the present invention is a class of conformation-controlled peptidomimetics to mimic dipeptides, can be used for the research and development of a new medicament taking polypeptide as a lead compound, and particularly can be used for the preparation of an IAPs inhibitor Xevinapant.
Inventors:
SUN HAIYING (CN)
ZHANG YANZHI (CN)
LI ZHILONG (CN)
ZHANG YANZHI (CN)
LI ZHILONG (CN)
Application Number:
PCT/CN2023/100643
Publication Date:
December 28, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07K5/078; A61K31/551; A61K38/05; C07D487/04; C07K5/065
Foreign References:
| CN111606970A | 2020-09-01 | |||
| CN111560017A | 2020-08-21 | |||
| CN105585583A | 2016-05-18 | |||
| CN101484151A | 2009-07-15 | |||
| CN102827063A | 2012-12-19 | |||
| AU2020380818A1 | 2022-06-02 |
Other References:
HAN KAI-LIN, GAO QIAN-QIAN, LIU WEN-LI, WANG GUO-CHENG: "Advances in Clinical Research of IAPs Antagonists", CHINA JOURNAL OF PHARMACEUTICAL ECONOMICS, vol. 14, no. 6, 1 January 2019 (2019-01-01), pages 123 - 128, XP093118661, ISSN: 1673-5846, DOI: 10.12010/j.issn.1673-5846.2019.06.031
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
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