PREPARATION METHOD FOR AND INTERMEDIATE OF 5'-NUCLEOSIDE PRODRUG

WIPO Patent Application WO/2022/127920

A1

Provided in the present invention are a preparation method for and an intermediate of a 5'-nucleoside prodrug. Specifically, provided in the present invention is a method for preparing a compound of formula VI. The method comprises the steps of: (a) reacting a compound of formula I and a compound of formula II to obtain a compound of formula III; (b) reacting the compound of formula III and reagent M to obtain a compound of formula IV; (c) reacting the compound of formula IV in the presence of reagent N to obtain a compound of formula V; and (d) reacting the compound of formula V with reagent O to obtain a compound of formula VI. The preparation method provided by the present invention has the advantages of having low costs, high yield, good product purity and the like, and is capable of achieving the efficient synthesis of 5'-nucleoside prodrugs.

JPH0597834	2,3,6-TRIMETHYL-5-(TETRAHYDROFURAN-2-YL)BENZOQUINONE
WO/2004/009065	HYPOGLYCEMIC AGENT, LIVER PROTECTING AGENT AND ANTICANCER AGENT CONTAINING LIGNANS ORIGINATING IN HONGDOUSHAN

SHEN JINGSHAN (CN)
HU TIANWEN (CN)
XIE YUANCHAO (CN)
ZHU FUQIANG (CN)

PCT/CN2021/139339

June 23, 2022

December 17, 2021

Click for automatic bibliography generation  

TOPHARMAN SHANGHAI CO LTD (CN)

C07D307/12; C07H19/06; C07D307/18; C07H19/14; C07H19/16

CN112074506A	2020-12-11
CN105273023A	2016-01-27
CN101657462A	2010-02-24
CN108440626A	2018-08-24
CN101469008A	2009-07-01

OYELERE ADEGBOYEGA K., STROBEL SCOTT A.: "Biochemical Detection of Cytidine Protonation within RNA", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 122, no. 42, 1 October 2000 (2000-10-01), pages 10259 - 10267, XP055942382, ISSN: 0002-7863, DOI: 10.1021/ja001918t

XU&PARTNERS, LLC. (CN)

View/Download PDF      PDF Help

Previous Patent: SURFACE DEFECT DETECTION METHOD, APPARATUS, SYSTEM, STORAGE MEDIUM, AND PROGRAM PRODUCT

Next Patent: VALVE CLIP REMOVAL DEVICE