Title:
PREPARATION METHOD FOR ISAVUCONAZONIUM SULFATE
Document Type and Number:
WIPO Patent Application WO/2024/037212
Kind Code:
A1
Abstract:
A preparation method for isavuconazonium sulfate, comprising the following steps: dissolving an iodized salt of isavuconazolium in a reaction solvent, adding sulfuric acid to remove tert-butoxycarbonyl, removing the solvent and collecting a precipitate; performing at least one extraction and impurity removal on the precipitates by using a lipid solvent, and collecting a first aqueous phase; performing at least one ion exchange treatment on the first aqueous phase by using a styrene-based hydrogen sulfate anion exchange resin, and collecting a second aqueous phase; and performing at least one extraction and impurity removal on the second aqueous phase by using a chloroalkane solvent, collecting a third aqueous phase, and performing lyophilization to prepare isavuconazonium sulfate.
Inventors:
NIU JIAN (CN)
LI YANLEI (CN)
PENG CHUNRUI (CN)
YANG JINGZE (CN)
LI YANLEI (CN)
PENG CHUNRUI (CN)
YANG JINGZE (CN)
Application Number:
PCT/CN2023/103764
Publication Date:
February 22, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
YANGTZE RIVER PHARMACEUTICAL GROUP SHANGHAI HAINI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D417/14
Domestic Patent References:
| WO2016016766A2 | 2016-02-04 |
Foreign References:
| CN115215857A | 2022-10-21 | |||
| CN110128420A | 2019-08-16 | |||
| CN106916152A | 2017-07-04 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
Download PDF:
Previous Patent: SHADING METHOD, SHADING APPARATUS, AND ELECTRONIC DEVICE
Next Patent: AIRPORT LIGHTING SIMULATION ANALYSIS METHOD
Next Patent: AIRPORT LIGHTING SIMULATION ANALYSIS METHOD