Title:
PREPARATION METHOD FOR OLFACTORY PRECURSOR CELL
Document Type and Number:
WIPO Patent Application WO/2021/093550
Kind Code:
A1
Abstract:
Provided is a preparation method for an olfactory precursor cell. Also provided is an olfactory precursor cell obtained according to the method, wherein the individual cell of the olfactory precursor cell can be continuously passaged for 11 or more generations. Compared with the prior art, the preparation method for the olfactory precursor cell has a good effect, can obtain a large number of olfactory precursor cells, is simple and feasible, has a low cost and good safety, and has a good application prospect at home and abroad.
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Inventors:
HUANG HONGYUN (CN)
GAO WENYONG (CN)
LIU YING (CN)
GAO WENYONG (CN)
LIU YING (CN)
Application Number:
PCT/CN2020/123101
Publication Date:
May 20, 2021
Filing Date:
October 23, 2020
Export Citation:
Assignee:
BEIJING HONGTIANJI NEUROSCIENCE ACAD (CN)
International Classes:
C12N5/071
Foreign References:
| CN105062956A | 2015-11-18 | |||
| CN101429497A | 2009-05-13 | |||
| CN101591641A | 2009-12-02 | |||
| CN105349491A | 2016-02-24 | |||
| CN201510935540A | 2015-12-15 | |||
| CN201510516055A | 2015-08-21 |
Other References:
SCHWOB JAMES E., JANG WOOCHAN, HOLBROOK ERIC H., LIN BRIAN, HERRICK DANIEL B., PETERSON JESSE N., HEWITT COLEMAN JULIE: "Stem and Progenitor Cells of the Mammalian Olfactory Epithelium: Taking Poietic License.", THE JOURNAL OF COMPARATIVE NEUROLOGY, vol. 525, no. 4, 25 August 2016 (2016-08-25), pages 1034 - 1054, XP055812540, ISSN: 0021-9967, DOI: 10.1002/cne.24105
XIAO MING: "Transplants of Human Adult Olfactory Neural Progenitors Repair the Spinal Cord Injury: An Experimental Study in Rats", CHINESE DOCTORAL DISSERTATIONS & MASTER'S THESES FULL-TEXT DATABASE (DOCTOR), 1 April 2005 (2005-04-01), pages 1 - 142, XP055812543
CHEN HENG, SONG ZHENTAO, LIU XIAODUN, QU TINGYU: "A Preliminary Study on Culture and Identification of Olfactory Ensheathing Cells from Human Middle Turbinate", CHINESE JOURNAL OF CELL AND STEM CELL(ELECTRONIC EDITION), vol. 9, no. 5, 1 October 2019 (2019-10-01), pages 262 - 266, XP055812547, ISSN: 2095-1221, DOI: 10.3877/cma.j.issn.2095-1221.2019.05.002
YU-ICHIRO OHNISHI , KOICHI IWATSUKI , MASAHIRO ISHIHARA , TAKASHI SHIKINA , KOEI SHINZAWA , TAKASHI MORIWAKI , KOSHI NINOMIYA , TO: "Isolation of Human Adult Olfactory Sphere Cells as a Cell Source of Neural Progenitors.", STEM CELL RESEARCH, vol. 15, no. 1, 29 April 2015 (2015-04-29), pages 23 - 29, XP055689057, ISSN: 1873-5061, DOI: 10.1016/j.scr.2015.04.006
JIMéNEZ-VACA ANA L.; BENITEZ-KING GLORIA; RUIZ VÃÂCTOR; RAMÃÂREZ-RODRÃÂGUEZ GERARDO B.; HERNáNDEZ-DE LA CRUZ BEATRIZ; : "Exfoliated Human Olfactory Neuroepithelium: A Source of Neural Progenitor Cells", MOLECULAR NEUROBIOLOGY, vol. 55, no. 3, 8 April 2017 (2017-04-08), pages 2516 - 2523, XP036449987, ISSN: 0893-7648, DOI: 10.1007/s12035-017-0500-z
See also references of EP 4060025A4
XIAO MING: "Transplants of Human Adult Olfactory Neural Progenitors Repair the Spinal Cord Injury: An Experimental Study in Rats", CHINESE DOCTORAL DISSERTATIONS & MASTER'S THESES FULL-TEXT DATABASE (DOCTOR), 1 April 2005 (2005-04-01), pages 1 - 142, XP055812543
CHEN HENG, SONG ZHENTAO, LIU XIAODUN, QU TINGYU: "A Preliminary Study on Culture and Identification of Olfactory Ensheathing Cells from Human Middle Turbinate", CHINESE JOURNAL OF CELL AND STEM CELL(ELECTRONIC EDITION), vol. 9, no. 5, 1 October 2019 (2019-10-01), pages 262 - 266, XP055812547, ISSN: 2095-1221, DOI: 10.3877/cma.j.issn.2095-1221.2019.05.002
YU-ICHIRO OHNISHI , KOICHI IWATSUKI , MASAHIRO ISHIHARA , TAKASHI SHIKINA , KOEI SHINZAWA , TAKASHI MORIWAKI , KOSHI NINOMIYA , TO: "Isolation of Human Adult Olfactory Sphere Cells as a Cell Source of Neural Progenitors.", STEM CELL RESEARCH, vol. 15, no. 1, 29 April 2015 (2015-04-29), pages 23 - 29, XP055689057, ISSN: 1873-5061, DOI: 10.1016/j.scr.2015.04.006
JIMéNEZ-VACA ANA L.; BENITEZ-KING GLORIA; RUIZ VÃÂCTOR; RAMÃÂREZ-RODRÃÂGUEZ GERARDO B.; HERNáNDEZ-DE LA CRUZ BEATRIZ; : "Exfoliated Human Olfactory Neuroepithelium: A Source of Neural Progenitor Cells", MOLECULAR NEUROBIOLOGY, vol. 55, no. 3, 8 April 2017 (2017-04-08), pages 2516 - 2523, XP036449987, ISSN: 0893-7648, DOI: 10.1007/s12035-017-0500-z
See also references of EP 4060025A4
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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