Title:
PREPARATION METHOD OF QUINOLINONE COMPOUND, AND USE THEREOF AS ANTIVIRAL AGENT AGAINST HERPES SIMPLEX VIRUS TYPE 1
Document Type and Number:
WIPO Patent Application WO/2017/036129
Kind Code:
A1
Abstract:
The present invention provides a use of a quinolinone compound of formula I or formula II or a pharmaceutically acceptable salt thereof in preparing an antiviral agent against herpes simplex virus type 1 (HSV-1), and a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof.
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Inventors:
SHAO CHANGLUN (CN)
WANG CHANGYUN (CN)
XU RUFANG (CN)
GUAN FEIFEI (CN)
WEI MEIYAN (CN)
WANG CHANGYUN (CN)
XU RUFANG (CN)
GUAN FEIFEI (CN)
WEI MEIYAN (CN)
Application Number:
PCT/CN2016/077663
Publication Date:
March 09, 2017
Filing Date:
March 29, 2016
Export Citation:
Assignee:
THE OCEAN UNIV OF CHINA (CN)
International Classes:
A61K31/4709; A61K31/4704; A61P31/22
Foreign References:
| CN103554090A | 2014-02-05 |
Other References:
SCOTT A. NEFF ET AL.: "Aflaquinolones A-G: Secondary metabolites from Marine and Fungicolous Isolates of Aspergillus spp.", J. NAT. PROD, vol. 75, no. 3, 23 March 2012 (2012-03-23), pages 464 - 472, XP055087611
KIRSTIN SCHERLACH ET AL.: "Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining", ORG. BIOMOL. CHEM., vol. 4, no. 18, 10 August 2006 (2006-08-10), pages 3517 - 3520, XP009123186
RYUJI UCHIDA ET AL.: "Yaequinolones, New Insectidial Antibiotics Produced by Penicillium sp. FKI-2140,", J. ANTIBIOT, vol. 59, no. 10, 31 December 2006 (2006-12-31), pages 646 - 651, XP009098247
MIYAKO KUSANO ET AL.: "Nematicidal Alkaloids and Related Compounds Produced by the Fungus Penicillium cf. simplicissimum", BIOSCI.BIOTECH. BIOCHEM., vol. 64, no. 12, 2000, pages 2559 - 2568, XP055011293
YI ZHANG ET AL.: "A new quinolinone and its natural /artificial derivatives from a shark gill-derived fungus Penicillium crustosum AP 2T1", NATURAL PRODUCT RESEARCH, vol. 31, no. 9, 17 July 2015 (2015-07-17), pages 985 - 989, XP055373217
SCOTT A. NEFF ET AL.: "Aflaquinolones A-G: Secondary Metabolites from Marine and Fungicolous Isolates of Aspergillus spp.", J. NAT. PROD., vol. 75, no. 3, 23 March 2012 (2012-03-23), pages 464 - 472, XP055087611
KIRSTIN SCHERLACH ET AL.: "Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining", ORG. BIOMOL. CHEM., vol. 4, no. 18, 10 August 2006 (2006-08-10), pages 3517 - 3520, XP009123186
RYUJI UCHIDA ET AL.: "Yaequinolones, New Insectidial Antibiotics Produced by Penicillium sp. FKI-2140,", J. ANTIBIOT, vol. 59, no. 10, 31 December 2006 (2006-12-31), pages 646 - 651, XP009098247
MIYAKO KUSANO ET AL.: "Nematicidal Alkaloids and Related Compounds Produced by the Fungus Penicillium cf. simplicissimum", BIOSCI.BIOTECH. BIOCHEM., vol. 64, no. 12, 2000, pages 2559 - 2568, XP055011293
YI ZHANG ET AL.: "A new quinolinone and its natural /artificial derivatives from a shark gill-derived fungus Penicillium crustosum AP 2T1", NATURAL PRODUCT RESEARCH, vol. 31, no. 9, 17 July 2015 (2015-07-17), pages 985 - 989, XP055373217
SCOTT A. NEFF ET AL.: "Aflaquinolones A-G: Secondary Metabolites from Marine and Fungicolous Isolates of Aspergillus spp.", J. NAT. PROD., vol. 75, no. 3, 23 March 2012 (2012-03-23), pages 464 - 472, XP055087611
Attorney, Agent or Firm:
QINGDAO LZ PATENT AND TRADEMARK OFFICE CO.,LTD. (CN)
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