Title:
PREPARATION METHOD FOR VACCINE LOADED WITH CANCER CELL WHOLE-CELL COMPONENT AND MIXED MEMBRANE COMPONENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/000724
Kind Code:
A1
Abstract:
Provided are a preparation method for a vaccine loaded with a cancer cell whole-cell component and a mixed membrane component and use thereof. The preparation method comprises the following steps: S1: obtaining the membrane component of a cancer cell; S2: activating an antigen-presenting cell and obtain the membrane component thereof; S3: obtaining the membrane component of a bacterium; and S4: allowing the products of S1 and S2 and/or the products of S1 and S3 to co-act with a second particle, such that the membrane components are loaded onto the second particle to obtain the vaccine. Vaccines derived from tumor tissues or cancer cells can be loaded with broad-spectrum various cancer cell antigens and mixed membrane components on the surface at the same time, which endow the vaccines with appropriate bionic membrane characteristics. The method provided can be used to prepare cancer vaccines loaded with broad-spectrum cancer cell antigenic epitopes, which can be used for preventing and treating various types of cancer.
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Inventors:
LIU MI (CN)
Application Number:
PCT/CN2022/108965
Publication Date:
January 04, 2024
Filing Date:
July 29, 2022
Export Citation:
Assignee:
SUZHOU ERSHENG BIOMEDICAL CO LTD (CN)
International Classes:
A61K39/00; A61K9/14; A61K9/16; A61K9/50; A61K9/51; A61K39/39; A61K39/395; A61K47/34; A61P35/00
Foreign References:
| CN113440605A | 2021-09-28 | |||
| CN110090298A | 2019-08-06 | |||
| CN113663060A | 2021-11-19 |
Other References:
CHENG SHANSHAN, XU CONG, JIN YUE, LI YU, ZHONG CHENG, MA JUN, YANG JIANI, ZHANG NAN, LI YUAN, WANG CHAO, YANG ZHIYOU, WANG YU: "Artificial Mini Dendritic Cells Boost T Cell–Based Immunotherapy for Ovarian Cancer", ADVANCED SCIENCE, vol. 7, no. 7, 1 April 2020 (2020-04-01), XP093113661, ISSN: 2198-3844, DOI: 10.1002/advs.201903301
WANG DONGDONG, LIU CONGHUI, YOU SHIQUAN, ZHANG KAI, LI MENG, CAO YU, WANG CHANGTAO, DONG HAIFENG, ZHANG XUEJI: "Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 37, 16 September 2020 (2020-09-16), US , pages 41138 - 41147, XP093121938, ISSN: 1944-8244, DOI: 10.1021/acsami.0c13169
CHEN LONG, QIN HAO, ZHAO RUIFANG, ZHAO XIAO, LIN LIANGRU, CHEN YANG, LIN YIXUAN, LI YAO, QIN YUTING, LI YIYE, LIU SHAOLI, CHENG KE: "Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines", SCIENCE TRANSLATIONAL MEDICINE, vol. 13, no. 601, 7 July 2021 (2021-07-07), pages eabc2816, XP093121940, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.abc2816
ZENG, YINGPING ET AL.: "Cell membrane coated-nanoparticles for cancer immunotherapy", ACTA PHARM SIN B, vol. 12, no. 8, 28 February 2022 (2022-02-28), pages 3233 - 3254, XP093119283, DOI: 10.1016/j.apsb.2022.02.023
WANG DONGDONG, LIU CONGHUI, YOU SHIQUAN, ZHANG KAI, LI MENG, CAO YU, WANG CHANGTAO, DONG HAIFENG, ZHANG XUEJI: "Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 37, 16 September 2020 (2020-09-16), US , pages 41138 - 41147, XP093121938, ISSN: 1944-8244, DOI: 10.1021/acsami.0c13169
CHEN LONG, QIN HAO, ZHAO RUIFANG, ZHAO XIAO, LIN LIANGRU, CHEN YANG, LIN YIXUAN, LI YAO, QIN YUTING, LI YIYE, LIU SHAOLI, CHENG KE: "Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines", SCIENCE TRANSLATIONAL MEDICINE, vol. 13, no. 601, 7 July 2021 (2021-07-07), pages eabc2816, XP093121940, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.abc2816
ZENG, YINGPING ET AL.: "Cell membrane coated-nanoparticles for cancer immunotherapy", ACTA PHARM SIN B, vol. 12, no. 8, 28 February 2022 (2022-02-28), pages 3233 - 3254, XP093119283, DOI: 10.1016/j.apsb.2022.02.023
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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