Title:
PREPARATION AND USE OF CHIMERIC ANTIGEN RECEPTOR IMMUNE CELL TARGETING CSF1R
Document Type and Number:
WIPO Patent Application WO/2023/246908
Kind Code:
A1
Abstract:
Provided are preparation and use of a chimeric antigen receptor immune cell targeting CSF1R. Specifically, provided is a chimeric antigen receptor (CAR) modified on the basis of a natural CSF1R ligand, the CAR comprising an extracellular binding domain capable of specifically targeting a CSF1 receptor. The CAR immune cell has high specificity and highly efficient killing capability, and in-vivo tests show that it has excellent tumor suppression capability.
Inventors:
ZHAO XUDONG (CN)
SUN BIN (CN)
MA HAIYAN (CN)
SUN BIN (CN)
MA HAIYAN (CN)
Application Number:
PCT/CN2023/101865
Publication Date:
December 28, 2023
Filing Date:
June 21, 2023
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07K19/00; A61K39/00; A61P35/00; C12N5/0783; C12N5/10; C12N15/62; C12N15/85; C12N15/867
Foreign References:
| CN115806626A | 2023-03-17 | |||
| CN115819614A | 2023-03-21 | |||
| CN108276495A | 2018-07-13 | |||
| CN105121466A | 2015-12-02 | |||
| CN113508129A | 2021-10-15 | |||
| CN105142659A | 2015-12-09 | |||
| CN106084030A | 2016-11-09 |
Other References:
ZHANG, PING ET AL.: "Effects of CSF1R-targeted chimeric antigen receptor-modified NK92MI & T cells on tumor-associated macrophages", IMMUNOTHERAPY, vol. 10, no. 11, 31 August 2018 (2018-08-31), pages 935 - 949, XP055981097, DOI: 10.2217/imt-2018-0012
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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