Title:
PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/208805
Kind Code:
A1
Abstract:
The present invention addresses the problem of finding an effective preventive and/or therapeutic agent for an autoimmune disease, in particular, pemphigus, pemphigoid or ANCA-related angiitis and thus providing the same as a medicine. A compound having a Btk inhibitory activity to be used in the present invention inhibits antibody production by B cells and, moreover, inhibits the formation of neutrophil extracellular traps (NETs). Thus, this compound is useful for preventing and/or treating an autoimmune disease, in particular, pemphigus, pemphigoid, nephrotic syndrome or ANCA-related angiitis.
Inventors:
ARIZA YUKO (JP)
Application Number:
PCT/JP2019/018054
Publication Date:
October 31, 2019
Filing Date:
April 26, 2019
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
A61K45/00; A61K31/4985; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/52; A61K31/522; A61P9/00; A61P13/12; A61P17/00; A61P37/06; A61P43/00
Domestic Patent References:
| WO2011152351A1 | 2011-12-08 | |||
| WO2011152351A1 | 2011-12-08 | |||
| WO2013081016A1 | 2013-06-06 | |||
| WO2008039218A2 | 2008-04-03 | |||
| WO2008121742A2 | 2008-10-09 | |||
| WO2013010868A1 | 2013-01-24 | |||
| WO2012170976A2 | 2012-12-13 | |||
| WO2013067274A1 | 2013-05-10 | |||
| WO2011162515A2 | 2011-12-29 | |||
| WO2009158571A1 | 2009-12-30 | |||
| WO2013185084A1 | 2013-12-12 | |||
| WO2014173289A1 | 2014-10-30 | |||
| WO2014039899A1 | 2014-03-13 | |||
| WO2014210085A1 | 2014-12-31 | |||
| WO2016065226A1 | 2016-04-28 |
Other References:
LEE, A. ET AL.: "Successful use of Bruton's kinase inhibitor, ibrutinib, to control paraneoplastic pemphigus in a patient with paraneoplastic autoimmune multiorgan syndrome and chronic lymphocytic leukemia", AUSTRALASIAN JOURNAL OF DERMATOLOGY, vol. 58, no. 4, 13 March 2017 (2017-03-13), pages e240 - e242, XP055649819
RANKIN, A. L. ET AL.: "Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis", J IMMUNOL., vol. 191, 2013, pages 4540 - 4550, XP055253077, DOI: 10.4049/jimmunol.1301553
KIM, Y. ET AL.: "HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus", ARTHRITIS RESEARCH & THERAPY, vol. 19, no. 1, 26 September 2017 (2017-09-26), pages 211, XP055649837
MURREL, D. ET AL.: "A pilot study of the efficacy of a bruton's tyrosine kinase inhibitor in the treatment of dogs with pemphigus foliaceus", AUSTRALASIAN JOURNAL OF DERMATOLOGY, vol. 58, no. S1, 2017, pages 73, XP055649827
CHALMERS, S. A. ET AL.: "Highly selective inhibition of Breton's tyrosine kinase attenuates skin and brain disease in murine lupus", ARTHRITIS RESEARCH & THERAPY, vol. 20, no. 10, 25 January 2018 (2018-01-25), pages 1 - 11, XP055649834
MUSUMECI, F ET AL.: "Pyrrolo[2, 3-d]pyrimidines active as Btk inhibitors", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 27, no. 12, 2017, pages 1305 - 1318, XP055465717, DOI: 10.1080/13543776.2017.1355908
MORIO, TOMOHIRO: "Neutrophil Overactivation Control Mechanisms and Inflammation", INFLAMMATION & IMMUNITY, vol. 21, no. 4, 2013, pages 345 - 351, XP009524716, ISSN: 0918-8371
ISHIZU , AKIHIRO: "Disorder of neutrophil extracellular traps in MPO-ANCA-associated vasculitis", JAPANESE JOURNAL OF PEDIATRIC NEPHROLOGY, vol. 27, no. 2, 2014, pages 81 - 85, XP055649840
ISHIZU, AKIHIRO: "Antineutrophil Cytoplasmic Antibodies and Neutrophil Extracellular Traps", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (IGAKU NO AYUMI), vol. 256, no. 12, 19 March 2016 (2016-03-19), pages 1209 - 1213, XP009524736, ISSN: 0039-2359
JAPANESE JOURNAL OF PEDIATRIC NEPHROLOGY, vol. 27, no. 2, 15 November 2014 (2014-11-15)
CAS, no. 1691249-45-2
"CAS", Database accession no. 1420477-60-6
J. IMMUNOL., vol. 183, 2009, pages 3980 - 3988
J. IMMUNOL., vol. 191, 2013, pages 4540 - 4550
RANKIN, A. L. ET AL.: "Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis", J IMMUNOL., vol. 191, 2013, pages 4540 - 4550, XP055253077, DOI: 10.4049/jimmunol.1301553
KIM, Y. ET AL.: "HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus", ARTHRITIS RESEARCH & THERAPY, vol. 19, no. 1, 26 September 2017 (2017-09-26), pages 211, XP055649837
MURREL, D. ET AL.: "A pilot study of the efficacy of a bruton's tyrosine kinase inhibitor in the treatment of dogs with pemphigus foliaceus", AUSTRALASIAN JOURNAL OF DERMATOLOGY, vol. 58, no. S1, 2017, pages 73, XP055649827
CHALMERS, S. A. ET AL.: "Highly selective inhibition of Breton's tyrosine kinase attenuates skin and brain disease in murine lupus", ARTHRITIS RESEARCH & THERAPY, vol. 20, no. 10, 25 January 2018 (2018-01-25), pages 1 - 11, XP055649834
MUSUMECI, F ET AL.: "Pyrrolo[2, 3-d]pyrimidines active as Btk inhibitors", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 27, no. 12, 2017, pages 1305 - 1318, XP055465717, DOI: 10.1080/13543776.2017.1355908
MORIO, TOMOHIRO: "Neutrophil Overactivation Control Mechanisms and Inflammation", INFLAMMATION & IMMUNITY, vol. 21, no. 4, 2013, pages 345 - 351, XP009524716, ISSN: 0918-8371
ISHIZU , AKIHIRO: "Disorder of neutrophil extracellular traps in MPO-ANCA-associated vasculitis", JAPANESE JOURNAL OF PEDIATRIC NEPHROLOGY, vol. 27, no. 2, 2014, pages 81 - 85, XP055649840
ISHIZU, AKIHIRO: "Antineutrophil Cytoplasmic Antibodies and Neutrophil Extracellular Traps", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (IGAKU NO AYUMI), vol. 256, no. 12, 19 March 2016 (2016-03-19), pages 1209 - 1213, XP009524736, ISSN: 0039-2359
JAPANESE JOURNAL OF PEDIATRIC NEPHROLOGY, vol. 27, no. 2, 15 November 2014 (2014-11-15)
CAS, no. 1691249-45-2
"CAS", Database accession no. 1420477-60-6
J. IMMUNOL., vol. 183, 2009, pages 3980 - 3988
J. IMMUNOL., vol. 191, 2013, pages 4540 - 4550
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Download PDF:
Previous Patent: MEDICAL INFORMATION PROCESSING SYSTEM AND MEDICAL INFORMATION PROCESSING PROGRAM
Next Patent: BATTERY
Next Patent: BATTERY