Title:
PRMT5 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2024/022433
Kind Code:
A1
Abstract:
Provided is a class of PRMT5 inhibitors represented by formula (X) or pharmaceutically acceptable salts, isotopic variants, tautomers, stereoisomers, prodrugs, polymorphs, hydrates or solvates thereof. Further provided are a preparation method for the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds in the prevention and treatment of cancers.
Inventors:
YANG XU (CN)
MENG QINGHUA (CN)
LIU LEI (CN)
WANG HUTING (CN)
SHI LEI (CN)
DU HAOLIN (CN)
GAO BEIRONG (CN)
WANG JIANHAO (CN)
KONG DESHENG (CN)
MENG QINGHUA (CN)
LIU LEI (CN)
WANG HUTING (CN)
SHI LEI (CN)
DU HAOLIN (CN)
GAO BEIRONG (CN)
WANG JIANHAO (CN)
KONG DESHENG (CN)
Application Number:
PCT/CN2023/109524
Publication Date:
February 01, 2024
Filing Date:
July 27, 2023
Export Citation:
Assignee:
BEIJING EARTHWISE TECH CO LTD (CN)
International Classes:
C07D213/75; A61K31/437; A61K31/4406; A61P35/00; C07D401/12; C07D401/14; C07D471/04
Domestic Patent References:
| WO2023146987A1 | 2023-08-03 | |||
| WO2022026892A1 | 2022-02-03 | |||
| WO2021004547A1 | 2021-01-14 |
Foreign References:
| US11077101B1 | 2021-08-03 |
Other References:
BOGOLUBSKY ANDREY V., MOROZ YURII S., MYKHAILIUK PAVEL K., PIPKO SERGEY E., ZHEMERA ANTON V., KONOVETS ANZHELIKA I., STEPANIUK OLE: "2,2,2-Trifluoroethyl Chlorooxoacetate—Universal Reagent for One-Pot Parallel Synthesis of N 1 -Aryl- N 2 -alkyl-Substituted Oxamides", ACS COMBINATIONAL SCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 10, 12 October 2015 (2015-10-12), US , pages 615 - 622, XP093034800, ISSN: 2156-8952, DOI: 10.1021/acscombsci.5b00091
ZACUTO MICHAEL J.: "Synthesis of Acrylamides via the Doebner–Knoevenagel Condensation", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 84, no. 10, 17 May 2019 (2019-05-17), pages 6465 - 6474, XP093134542, ISSN: 0022-3263, DOI: 10.1021/acs.joc.9b00450
ZACUTO MICHAEL J.: "Synthesis of Acrylamides via the Doebner–Knoevenagel Condensation", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 84, no. 10, 17 May 2019 (2019-05-17), pages 6465 - 6474, XP093134542, ISSN: 0022-3263, DOI: 10.1021/acs.joc.9b00450
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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