Title:
PROBE FOR NUCLEAR MEDICAL TESTING
Document Type and Number:
WIPO Patent Application WO/2023/145967
Kind Code:
A1
Abstract:
[Problem] To provide a novel compound that is promising as a probe for nuclear medical testing. [Solution] Provided is a compound represented by general formula (I) or a salt thereof.
Inventors:
URANO YASUTERU (JP)
KAMIYA MAKO (JP)
ABE ATSUKI (JP)
FUJII HIROFUMI (JP)
OHNUKI KAZUNOBU (JP)
KAMIYA MAKO (JP)
ABE ATSUKI (JP)
FUJII HIROFUMI (JP)
OHNUKI KAZUNOBU (JP)
Application Number:
PCT/JP2023/003072
Publication Date:
August 03, 2023
Filing Date:
January 31, 2023
Export Citation:
Assignee:
UNIV TOKYO (JP)
NAT CANCER CT (JP)
NAT CANCER CT (JP)
International Classes:
C07C233/15; A61K51/00; A61K51/04
Foreign References:
| JPH08510259A | 1996-10-29 |
Other References:
DAISUKE ASANUMA, ET AL.: "Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo", NATURE COMMUNICATIONS, vol. 6, no. 7463, 1 December 2015 (2015-12-01), pages 1 - 7, XP055451716, DOI: 10.1038/ncomms7463
URANO, YASUTERU; SAKABE, MASAYO; KOSAKA, NOBUYUKI; OGAWA, MIKAKO; MITSUNAGA, MAKOTO; ASANUMA, DAISUKE; KAMIYA, MAKO; YOUNG, MATTHE: "Rapid cancer detection by topically spraying a .gamma.-glutamyltranspeptidase-activated fluorescent probe", SCIENCE TRANSLATIONAL MEDICINE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE (A A A S), US, vol. 3, no. 110, 1 January 2011 (2011-01-01), US , pages 110ra119,152 - 161, XP008177620, ISSN: 1946-6242, DOI: 10.1126/scitranslmed.3002823
BAI BING, YAN CHENXU, ZHANG YUTAO, GUO ZHIQIAN, ZHU WEI-HONG: "Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 54, no. 87, 30 October 2018 (2018-10-30), UK , pages 12393 - 12396, XP093080579, ISSN: 1359-7345, DOI: 10.1039/C8CC07376G
URANO, YASUTERU; SAKABE, MASAYO; KOSAKA, NOBUYUKI; OGAWA, MIKAKO; MITSUNAGA, MAKOTO; ASANUMA, DAISUKE; KAMIYA, MAKO; YOUNG, MATTHE: "Rapid cancer detection by topically spraying a .gamma.-glutamyltranspeptidase-activated fluorescent probe", SCIENCE TRANSLATIONAL MEDICINE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE (A A A S), US, vol. 3, no. 110, 1 January 2011 (2011-01-01), US , pages 110ra119,152 - 161, XP008177620, ISSN: 1946-6242, DOI: 10.1126/scitranslmed.3002823
BAI BING, YAN CHENXU, ZHANG YUTAO, GUO ZHIQIAN, ZHU WEI-HONG: "Dual-channel near-infrared fluorescent probe for real-time tracking of endogenous γ-glutamyl transpeptidase activity", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 54, no. 87, 30 October 2018 (2018-10-30), UK , pages 12393 - 12396, XP093080579, ISSN: 1359-7345, DOI: 10.1039/C8CC07376G
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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