Title:
PROCESS FOR THE MANUFACTURE OF OPTICALLY ACTIVE 3-SUBSTITUTED LACTAMS BY ASYMMETRIC HYDROGENATION OF 3-ALKYLIDENELACTAMS
Document Type and Number:
WIPO Patent Application WO2003079975
Kind Code:
A3
Abstract:
The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) [Insert chemical formula here] process, comprising: contacting a compound of formula (II): [Insert chemical formula here] with hydrogen under a suitable pressure in the presence of an iridium complex of the formula (R<2>)IrL<+>X<-> wherein L is a chelating diene, X is a non coordinating anion, and R<2> is selected from . [Insert chemical formula here]
Inventors:
NUGENT WILLIAM A (US)
YUE TAI Y (US)
YUE TAI Y (US)
Application Number:
PCT/US2003/007811
Publication Date:
March 18, 2004
Filing Date:
March 15, 2003
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
NUGENT WILLIAM A (US)
YUE TAI Y (US)
NUGENT WILLIAM A (US)
YUE TAI Y (US)
International Classes:
B01J31/24; C07B53/00; C07B61/00; C07D207/26; C07D207/263; C07D207/267; C07D211/76; C07D223/10; C07D405/06; (IPC1-7): C07D207/12; C07D211/40
Other References:
YUE ET AL.: "Enantioselective hydrogenation of 3-alkylidenelactams: High-Throughput screening provides a surprising solution", JOURNAL OF CHEMICAL SOCIETY, vol. 124, pages 13692 - 13693, XP002969689
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