A SUBSTANCE WITH SEDATIVE EFFECT - TECHNOLOGY COMMERCIALIZATION

Title:

A SUBSTANCE WITH SEDATIVE EFFECT

Document Type and Number:

WIPO Patent Application WO2003079976

Kind Code:

A3

Abstract:

A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid, meconic acid, chelidonic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 5 and 200 mg of active ingredient per kilogram of a body weight of a patient, the substance can be used to treat various neurotic disorders such as insomnia, anxiety, neurosis, depression as well as withdrawal symptoms for drug addiction patients, especially for patients addicted to opioid-based drugs. The substance can be delivered in a number of ways of systemic administration of a pharmaceutical agent including oral, parenteral, transdermal, and transmucosal administration. For drug addicted patients, the preferred method of administration involves a subcutaneous implant providing a continuous release of an active ingredient at an effective daily rate over the entire treatment period ranging from 5 to 30 days, and preferably from 13 to 20 days.

Inventors:

KRYLOV BORIS VLADIMIROVICH (RU)
SHCHEGOLEV BORIS FEDOROVICH (RU)

Application Number:

PCT/US2003/007827

Publication Date:

August 26, 2004

Filing Date:

March 14, 2003

Export Citation:

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Assignee:

TECHNOLOGY COMMERCIALIZATION (US)
KRYLOV BORIS VLADIMIROVICH (RU)
SHCHEGOLEV BORIS FEDOROVICH (RU)

International Classes:

A61K31/351; A61K9/22; A61K9/52; A61K9/62; A61K31/35; A61P25/20; (IPC1-7): A61F13/00; A61K9/14; A61K9/22; A61K9/52; A61K9/62

Foreign References:

US5411985A	1995-05-02
US4276890A	1981-07-07
US5219858A	1993-06-15
US4221723A	1980-09-09

Other References:

DATABASE WPI Week 197814, Derwent World Patents Index; AN 1978-26137A, XP002978567, "Colourless pharmaceutical compsn. for topical application - comprises pyrone cpd. such as kojic acid"
See also references of EP 1485050A4

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