Title:
PROCESS FOR PREPARATION OF 2−AMINOTETRALIN DERIVATIVES AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/046197
Kind Code:
A1
Abstract:
The invention relates to simple and efficient preparation of optically active 7−substituted−2−aminotetralins with industrial advantage. A process for preparation of optically active 7− substituted−2−aminotetralins or salts thereof, which comprises reducing a 7−substituted−2−tetralone or a bisulfite adduct thereof with a microorganism into an optically active 7−substituted−2−tetralol, introducing a sulfonyl group into the hydroxyl group of the tetralol to obtain an optically active 7−substituted−2−sulfonyloxytetralin, introducing a nitrogen substituent into the resulting tetralin by the use of a nitrogen nucleophile through inversion to obtain an optically active 2,7−substituted tetralin, and, if necessary, converting the nitrogen substituent into an unsubstituted amino group.
Inventors:
HONDA TATSUYA (JP)
FUJII AKIO (JP)
INOUE KENJI (JP)
YASOHARA YOSHIHIKO (JP)
ITAGAKI YOSHIFUMI (JP)
MAEHARA KATSUJI (JP)
TAKEDA TOSHIHIRO (JP)
UEDA YASUYOSHI (JP)
FUJII AKIO (JP)
INOUE KENJI (JP)
YASOHARA YOSHIHIKO (JP)
ITAGAKI YOSHIFUMI (JP)
MAEHARA KATSUJI (JP)
TAKEDA TOSHIHIRO (JP)
UEDA YASUYOSHI (JP)
Application Number:
PCT/JP2002/012409
Publication Date:
June 05, 2003
Filing Date:
November 28, 2002
Export Citation:
Assignee:
KANEKA CORP (JP)
HONDA TATSUYA (JP)
FUJII AKIO (JP)
INOUE KENJI (JP)
YASOHARA YOSHIHIKO (JP)
ITAGAKI YOSHIFUMI (JP)
MAEHARA KATSUJI (JP)
TAKEDA TOSHIHIRO (JP)
UEDA YASUYOSHI (JP)
HONDA TATSUYA (JP)
FUJII AKIO (JP)
INOUE KENJI (JP)
YASOHARA YOSHIHIKO (JP)
ITAGAKI YOSHIFUMI (JP)
MAEHARA KATSUJI (JP)
TAKEDA TOSHIHIRO (JP)
UEDA YASUYOSHI (JP)
International Classes:
C07C213/02; C07C303/28; C07C309/66; C07C309/73; C12P7/42; C07C217/74; (IPC1-7): C12P41/00; C07C213/02; C07C217/74; C07C309/66; C07C309/73; C07B55/00
Foreign References:
| EP0997535A2 | 2000-05-03 | |||
| JP2001294568A | 2001-10-23 | |||
| JP2000007624A | 2000-01-11 |
Other References:
PAOLO MANITTO ET AL.: "Baker's yeast mediated reduction of aromatic ring substituted 2-tetralones", TETRAHEDRON, vol. 51, no. 42, 1995, pages 11531 - 11546, XP002965245
AINA GABRIELLA ET AL.: "Asymmetric bioreduction of racemic 5,6,7,8-tetrahydro-8-methyl-1,3-dimethoxynaphthalen-6-one to the corresponding chiral beta-tetralols", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, vol. 11, 2001, pages 367 - 371, XP002965246
See also references of EP 1457570A4
AINA GABRIELLA ET AL.: "Asymmetric bioreduction of racemic 5,6,7,8-tetrahydro-8-methyl-1,3-dimethoxynaphthalen-6-one to the corresponding chiral beta-tetralols", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, vol. 11, 2001, pages 367 - 371, XP002965246
See also references of EP 1457570A4
Attorney, Agent or Firm:
Yasutomi, Yasuo (4-20 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, JP)
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