Title:
PROCESS FOR THE PREPARATION OF THIAZOLIDINEDIONE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/096321
Kind Code:
A1
Abstract:
An industrially advantageous process for the preparation of a benzylthiazolidinedione derivative useful as an intermediate in the preparation of N-benzyldioxothiazolidinyl-benzamide derivatives serving as antihyperglycemics. Specifically, a process for the preparation of a thiazolidinedione derivative of formula (1), characterized by forming a Co complex catalyst in a specified pH range in a reaction system where the subsequent reduction is to be carried out, and reducing a compound of the general formula (2) with a reducing agent in the resulting reaction system (2) (wherein R is hydrogen or lower alkyl).
Inventors:
OHNOTA MICHIRO (JP)
ORITA KAZUO (JP)
AIZAWA YASUHIRO (JP)
YOSHIDA NORIYUKI (JP)
SAKAMAKI TAKASHI (JP)
ORITA KAZUO (JP)
AIZAWA YASUHIRO (JP)
YOSHIDA NORIYUKI (JP)
SAKAMAKI TAKASHI (JP)
Application Number:
PCT/JP2001/004989
Publication Date:
December 20, 2001
Filing Date:
June 13, 2001
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
OHNOTA MICHIRO (JP)
ORITA KAZUO (JP)
AIZAWA YASUHIRO (JP)
YOSHIDA NORIYUKI (JP)
SAKAMAKI TAKASHI (JP)
OHNOTA MICHIRO (JP)
ORITA KAZUO (JP)
AIZAWA YASUHIRO (JP)
YOSHIDA NORIYUKI (JP)
SAKAMAKI TAKASHI (JP)
International Classes:
C07D277/20; C07D277/34; (IPC1-7): C07D277/34
Domestic Patent References:
| WO1996038428A1 | 1996-12-05 | |||
| WO1993013095A1 | 1993-07-08 |
Foreign References:
| JPH08277279A | 1996-10-22 |
Attorney, Agent or Firm:
Minoura, Kiyoshi (7th floor 2-2, Kudankita 3-chome Chiyoda-ku Tokyo, JP)
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