Title:
PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005077945
Kind Code:
A3
Abstract:
The invention relates to processes for preparing compounds having the formula (I) and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
Inventors:
CHEN BANG-CHI (US)
DROGHINI ROBERTO (CA)
LAJEUNESSE JEAN (CA)
DIMARCO JOHN D (US)
GALELLA MICHAEL (US)
CHIDAMBARAM RAMAKRISHNAN (US)
DROGHINI ROBERTO (CA)
LAJEUNESSE JEAN (CA)
DIMARCO JOHN D (US)
GALELLA MICHAEL (US)
CHIDAMBARAM RAMAKRISHNAN (US)
Application Number:
PCT/US2005/003728
Publication Date:
May 18, 2006
Filing Date:
February 04, 2005
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
CHEN BANG-CHI (US)
DROGHINI ROBERTO (CA)
LAJEUNESSE JEAN (CA)
DIMARCO JOHN D (US)
GALELLA MICHAEL (US)
CHIDAMBARAM RAMAKRISHNAN (US)
CHEN BANG-CHI (US)
DROGHINI ROBERTO (CA)
LAJEUNESSE JEAN (CA)
DIMARCO JOHN D (US)
GALELLA MICHAEL (US)
CHIDAMBARAM RAMAKRISHNAN (US)
International Classes:
C07C235/28; C07C237/42; C07D277/56; C07D417/12; C07D417/14; (IPC1-7): C07D277/56; C07D417/12; A61P31/04; A61P31/12; C07D277:00; C07D241:00; C07D239:00
Domestic Patent References:
| WO2004071440A2 | 2004-08-26 | |||
| WO2005072826A2 | 2005-08-11 |
Foreign References:
| US3547917A | 1970-12-15 | |||
| EP0639574A1 | 1995-02-22 | |||
| US6596746B1 | 2003-07-22 |
Other References:
ZHAO R ET AL: "A new facile synthesis of 2-aminothiazole-5-carboxylates", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 42, no. 11, 11 March 2001 (2001-03-11), pages 2101 - 2102, XP004229211, ISSN: 0040-4039
SHAH NEIL P ET AL: "Overriding imatinib resistance with a novel ABL kinase inhibitor.", SCIENCE. 16 JUL 2004, vol. 305, no. 5682, 16 July 2004 (2004-07-16), pages 399 - 401, XP002361026, ISSN: 1095-9203
SHAH NEIL P ET AL: "Overriding imatinib resistance with a novel ABL kinase inhibitor.", SCIENCE. 16 JUL 2004, vol. 305, no. 5682, 16 July 2004 (2004-07-16), pages 399 - 401, XP002361026, ISSN: 1095-9203
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