Title:
PROCESS FOR PREPARING BENZHYDRYLTHIOACETAMIDE
Document Type and Number:
WIPO Patent Application WO2004075841
Kind Code:
A3
Abstract:
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetamide is prepared in high yield and purity by the reaction of a haloacetamide with the reaction product of thiourea and benzhydrol in aqueous solution. The reaction employing the haloacetamide is conducted in a solvent comprising water and an organic solvent such as dimethylformamide having dissolved therein a basic salt such as potassium carbonate. The resulting benzhydrylthioacetamide can be oxidized to provide the pharmaceutical modafinil.
Inventors:
LIANG SIDNEY (US)
Application Number:
PCT/US2004/005265
Publication Date:
April 07, 2005
Filing Date:
February 23, 2004
Export Citation:
Assignee:
MALLINCKRODT INC (US)
LIANG SIDNEY (US)
LIANG SIDNEY (US)
International Classes:
C07C315/02; C07C315/06; C07C319/14; C07C335/32; C07C317/44; C07C323/60; (IPC1-7): C07C319/20; C07C323/60; C07C148/00; C07C149/273
Domestic Patent References:
| WO2002010125A1 | 2002-02-07 |
Foreign References:
| US20040002547A1 | 2004-01-01 | |||
| EP1260501A1 | 2002-11-27 | |||
| US4177290A | 1979-12-04 |
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