Title:
PROCESS FOR PREPARING BICYCLO AD3.3.0 BDOCTENES
Document Type and Number:
WIPO Patent Application WO/1986/002923
Kind Code:
A1
Abstract:
A process for preparing bicyclo AD3.3.0 BDoctenes represented by general formula (II), wherein R11 represents H, a mono-equivalent cation or R1, Romega' represents Romega, and R21 represents H or R2, from a thiol compound represented by general formula (I), wherein R1 represents a C1-10 alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted alicyclic group, a substituted or unsubstituted phenyl (C1-2) alkyl group or a tri(C1-7 hydrocarbyl)silyl group, Ar represents a substituted or unsubstituted aryl group, Romega represents a substituted or unsubstituted C1-13 alkyl group or a substituted or unsubstituted C2-13 alkenyl group, and R2 represents a hydroxy-protecting group. This process enables to obtain isocarbacyclines or synthetic intermediates therefor with industrial advantages.
Inventors:
IKEGAMI SHIRO (JP)
TORIZAWA YASUHIRO (JP)
KUROSUMI SEIZI (JP)
TORIZAWA YASUHIRO (JP)
KUROSUMI SEIZI (JP)
Application Number:
PCT/JP1985/000636
Publication Date:
May 22, 1986
Filing Date:
November 14, 1985
Export Citation:
Assignee:
TEIJIN LTD (JP)
International Classes:
C07C51/377; C07C67/00; C07C401/00; C07C405/00; C07F7/18; (IPC1-7): C07C59/46; C07C59/62; C07C69/732; C07C69/734; C07C154/00; C07D307/20; C07D309/12; C07F7/18
Other References:
J. Chem. Soc., Chem. Comm., Vol. 23, (December 1984) (England) TORISAWA YASUHIRO et al (A new Synthetic Route to (+)-Isocarbacyclin) pp. 1602-1603
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