Title:
PROCESS FOR PREPARING A CYCLIC AMINO ACID ANTICONVULSANT COMPOUND
Document Type and Number:
WIPO Patent Application WO1999018063
Kind Code:
A3
Abstract:
An improved process for the preparation of a cyclic amino acid of formula (I) by a novel synthesis is described where benzonitrile is treated with an alkali metal and an amine under Birch reduction conditions to generate in situ an anionic intermediate which is alkylated with an alpha -haloacetic acid moiety which is subsequently converted to the desired product, as well as valuable intermediates used in the process.
Inventors:
DEERING CARL FRANCIS (US)
MENNEN KENNETH EARL (US)
RAMAGE ROBERT (GB)
MENNEN KENNETH EARL (US)
RAMAGE ROBERT (GB)
Application Number:
PCT/US1998/019359
Publication Date:
June 24, 1999
Filing Date:
September 16, 1998
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
DEERING CARL FRANCIS (US)
MENNEN KENNETH EARL (US)
RAMAGE ROBERT (GB)
DEERING CARL FRANCIS (US)
MENNEN KENNETH EARL (US)
RAMAGE ROBERT (GB)
International Classes:
C07C227/04; C07C253/30; C07C255/46; C07C229/28; (IPC1-7): C07C255/46; C07C227/06; C07C253/30
Foreign References:
| US5132451A | 1992-07-21 |
Other References:
GARETH GRIFFITHS ET AL.: "Novel Syntheses of Gabapentin via Addition of Hydrocyanic Acid to Cyclohexylidenemalonate or Cyano(cyclohexylidene)acetate", HELVETICA CHIMICA ACTA, vol. 74, no. 2, 1991, BASEL CH, pages 309 - 314, XP002100736
ATHUR G. SCHULTZ ET AL.: "Birch Reduction and Reductive Alkylation of Benzonitriles and Benzamides", JOURNAL OF ORGANIC CHEMISTRY, vol. 51, no. 25, 12 December 1986 (1986-12-12), EASTON US, pages 4983 - 4987, XP002100737
ATHUR G. SCHULTZ ET AL.: "Birch Reduction and Reductive Alkylation of Benzonitriles and Benzamides", JOURNAL OF ORGANIC CHEMISTRY, vol. 51, no. 25, 12 December 1986 (1986-12-12), EASTON US, pages 4983 - 4987, XP002100737
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