Title:
PROCESS FOR PRODUCING 1-ARYLIMINO-2-VINYLCYCLOPROPANECARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2015/146881
Kind Code:
A1
Abstract:
The present invention is a process for producing a 1-arylimino-2-vinylcyclopropanecarboxylic acid derivative represented by formula (2) in a yield close to that attained with lithium t-butoxide, preferably in a yield higher than that attained with lithium t-butoxide, without causing any trouble in industrial-scale production, the process comprising reacting an N-(arylmethylene)glycine ester represented by formula (1) with (E)-1,4-dibromo-2-butene using sodium ethoxide.
The present invention further involves a process for producing a (1R,2S)-1-arylimino-2-vinylcyclopropanecarboxylic acid derivative represented by formula (4) by reacting an N-(arylmethylene)glycine ester represented by formula (1) with (E)-1,4-dibromo-2-butene using sodium ethoxide in the presence of an optically active catalyst.
Inventors:
MURATA TAKAHIKO (JP)
FUNABASHI MAKOTO (JP)
NISHIYAMA AKIRA (JP)
FUNABASHI MAKOTO (JP)
NISHIYAMA AKIRA (JP)
Application Number:
PCT/JP2015/058671
Publication Date:
October 01, 2015
Filing Date:
March 23, 2015
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07C251/16; C07C227/18; C07C227/32; C07C229/48; C07C249/02; C07B53/00; C07B61/00
Domestic Patent References:
| WO2011102388A1 | 2011-08-25 | |||
| WO2011019066A1 | 2011-02-17 | |||
| WO2013058241A1 | 2013-04-25 |
Foreign References:
| JP2012532146A | 2012-12-13 |
Other References:
See also references of EP 3124469A4
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
Hisakazu Ueki (JP)
Hisakazu Ueki (JP)
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