Title:
PROCESS FOR PRODUCING CYCLOPROPYLPHENOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/106906
Kind Code:
A1
Abstract:
A method of easily synthesizing a cyclopropylphenol derivative. The method, which is a process for producing a cyclopropylphenol derivative represented by the general formula (10): [wherein R1, R2, R3, and R4 each independently is hydrogen, etc.; Z is hydrogen, etc.; and Y1, Y2, and Y3 each independently is hydrogen, etc.], comprises reacting a compound represented by the general formula (7): [wherein the symbols have the same meanings as defined above; X is halogeno; and V is hydrogen, etc.] with a metal, metal salt, or organometallic compound represented by the general formula M2 (8) to obtain a compound represented by the general formula (9): [wherein the symbols have the same meanings as defined above]. When V is a -W-R5 group, hydrolysis is further conducted. Thus, a compound of the general formula (10) is obtained.
Inventors:
TSUKAMOTO YOSHIHISA
KOMAI HIROYUKI
KANEKO TOSHIO
TAKADA TAKESHI
KOMAI HIROYUKI
KANEKO TOSHIO
TAKADA TAKESHI
Application Number:
PCT/JP2006/306806
Publication Date:
October 12, 2006
Filing Date:
March 31, 2006
Export Citation:
Assignee:
SANKYO AGRO CO LTD (JP)
TSUKAMOTO YOSHIHISA
KOMAI HIROYUKI
KANEKO TOSHIO
TAKADA TAKESHI
TSUKAMOTO YOSHIHISA
KOMAI HIROYUKI
KANEKO TOSHIO
TAKADA TAKESHI
International Classes:
C07C39/17; C07C37/01; C07C39/19; C07C39/24; C07C67/297; C07C69/157; C07C69/635
Foreign References:
| JP2004002263A | 2004-01-08 | |||
| JPH02256684A | 1990-10-17 |
Other References:
CORBIN T.F. ET AL.: "Cyclopropylbenzene", ORGANIC SYNTHESES, vol. 44, 1964, pages 30 - 33, XP003001212
HAHN R.C. ET AL.: "Electrical Effects of Cycloalkyl Groups", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 90, no. 13, 1968, pages 3404 - 3415, XP003001213
GREENE T.W. ET AL.: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS THIRD EDITION", 1999, JOHN WILEY & SONS, INC., pages: 276 - 287, XP003001214
TALLEY J.J. ET AL.: "Reaction of Lithium o-Lithiophenoxide with Carbonyl Compounds", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 49, no. 26, 1984, pages 5267 - 5269, XP003001215
See also references of EP 1880987A4
HAHN R.C. ET AL.: "Electrical Effects of Cycloalkyl Groups", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 90, no. 13, 1968, pages 3404 - 3415, XP003001213
GREENE T.W. ET AL.: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS THIRD EDITION", 1999, JOHN WILEY & SONS, INC., pages: 276 - 287, XP003001214
TALLEY J.J. ET AL.: "Reaction of Lithium o-Lithiophenoxide with Carbonyl Compounds", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 49, no. 26, 1984, pages 5267 - 5269, XP003001215
See also references of EP 1880987A4
Attorney, Agent or Firm:
Tsukuni, Hajime (22-12 Toranomon 1-chome, Minato-k, Tokyo 01, JP)
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