Title:
PROCESS FOR PRODUCING ß-HYDROXYAMINO ACID DERIVATIVE AND INTERMEDIATE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2003/066578
Kind Code:
A1
Abstract:
A pinene derivative represented by the general formula (I) or a salt thereof; and a process for producing the derivative or salt or a process for producing from the derivative or salt an optionally active 2-(t-butoxycarbonyl)amino-3-hydroxypropanoic acid derivative represented by the general formula (V) (in the formulae, R1 represents alkyl and R2 represents alkyl, alkenyl, alkynyl, a cyclic group, etc.). The 2-(t-butoxycarbonyl)amino-3-hydroxypropanoic acid derivative, which is useful as an important intermediate for medicines, can be efficiently synthesized from the novel intermediate represented by the general formula (I).
Inventors:
MATSUNAGA NAOKI (JP)
HISAICHI KATSUYA (JP)
TAKAOKA YOSHIKAZU (JP)
HISAICHI KATSUYA (JP)
TAKAOKA YOSHIKAZU (JP)
Application Number:
PCT/JP2003/001239
Publication Date:
August 14, 2003
Filing Date:
February 06, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
MATSUNAGA NAOKI (JP)
HISAICHI KATSUYA (JP)
TAKAOKA YOSHIKAZU (JP)
MATSUNAGA NAOKI (JP)
HISAICHI KATSUYA (JP)
TAKAOKA YOSHIKAZU (JP)
International Classes:
C07B53/00; C07C227/04; C07C229/22; C07C249/02; C07C251/20; C07C269/04; C07C271/22; C07D339/08; (IPC1-7): C07C251/20; C07B53/00; C07C227/04; C07C229/22; C07C249/02; C07C269/04; C07C271/22; C07D307/42; C07D309/06; C07D309/22; C07D319/18; C07D335/02; C07D339/08
Other References:
SOLLADIE-CAVALLO ARLETTE ET AL.: "Full conversion in diastereoselective aldol additions using "naked" enolates under catalytic amount of phosphazene base", SYNLETT., no. 3, 2000, pages 327 - 330, XP002968871
SOLLADIE-CAVALLO ARLETTE ET AL.: "A four-step synthesis of erythro-m-chloro-3-hydroxytyrosine ethyl ester enantiomerically pure", TETRAHEDRON LETTERS, vol. 39, no. 15, 1998, pages 2191 - 2194, XP004110666
SOLLADIE-CAVALLO ARLETTE ET AL.: "Erythro-selective aldol condensation using directly generated Ti-enolates", GAZZETTA CHIMICA ITALIANA, vol. 126, no. 3, 1996, pages 173 - 178, XP002968872
SOLLADIE-CAVALLO ARLETTE ET AL.: "A four-step synthesis of erythro-m-chloro-3-hydroxytyrosine ethyl ester enantiomerically pure", TETRAHEDRON LETTERS, vol. 39, no. 15, 1998, pages 2191 - 2194, XP004110666
SOLLADIE-CAVALLO ARLETTE ET AL.: "Erythro-selective aldol condensation using directly generated Ti-enolates", GAZZETTA CHIMICA ITALIANA, vol. 126, no. 3, 1996, pages 173 - 178, XP002968872
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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