Title:
PROCESS FOR PRODUCING LIQUIRITIGENIN PRECURSOR
Document Type and Number:
WIPO Patent Application WO/2016/002848
Kind Code:
A1
Abstract:
[Problem] To provide a process suitable as a process for mass-producing liquiritigenin.
[Solution] A process for producing isoliquiritigenin, characterized by coupling a 4-alkoxycinnamic acid represented by formula (I) with a 1,3-alkoxybenzene represented by formula (II) through the Friedel-Crafts reaction (A) to synthesize a trialkoxyisoliquiritigenin represented by formula (III), crystallizing out the reaction product, and eliminating the protecting groups therefrom to obtain isoliquiritigenin, which is represented by formula (IV). The isoliquiritigenin, which is represented by formula (IV), is administered as a precursor for liquiritigenin to the body, thereby obtaining in vivo the pharmacological effect of the (-) isomer of liquiritigenin.
Inventors:
HIGO HARUO (JP)
MASUDA TOSHIYA (JP)
MASUDA TOSHIYA (JP)
Application Number:
PCT/JP2015/069021
Publication Date:
January 07, 2016
Filing Date:
July 01, 2015
Export Citation:
Assignee:
HIGO HARUO (JP)
International Classes:
C07C45/46; C07C45/65; C07C49/835; C07C49/84; C07D311/28
Domestic Patent References:
| WO1988004288A1 | 1988-06-16 |
Other References:
CHATURVEDI, R. ET AL.: "An improved procedure for flavanones", INDIAN JOURNAL OF CHEMISTRY, vol. 31 B, 1992, pages 340 - 341
YANG, L. ET AL.: "THE SYNTHESIS OF LIQUIRITIGENIN AND ISOLIQUIRITIGENIN", YAOXUE XUEBAO, vol. 29, no. 11, 1994, pages 877 - 880, XP055249647
YANG, L. ET AL.: "THE SYNTHESIS OF LIQUIRITIGENIN AND ISOLIQUIRITIGENIN", YAOXUE XUEBAO, vol. 29, no. 11, 1994, pages 877 - 880, XP055249647
Attorney, Agent or Firm:
ISHII, HISAO (JP)
Hisao Ishii (JP)
Hisao Ishii (JP)
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