Title:
PROCESS FOR PRODUCING MULTIPLE OLIGONUCLEOTIDES ON A SOLID SUPPORT
Document Type and Number:
WIPO Patent Application WO2002020541
Kind Code:
A3
Abstract:
A process for the production of the two or more molecules of interest. The present process may be advantageously used to produce two, three, four or more molecules of interest (the same or different from one another) on a single support material. A preferred embodiment comprises use of the present process to produce two or more oligonucleotides of interest. The process can be readily extended to other applications such as combinatorial chemistry, peptide synthesis and the like. Various novel intermediates in the process are also disclosed.
Inventors:
PON RICHARD T (CA)
SANGHVI YOGESH (US)
YU SHUYUAN (CA)
SANGHVI YOGESH (US)
YU SHUYUAN (CA)
Application Number:
PCT/CA2001/001244
Publication Date:
August 22, 2002
Filing Date:
September 05, 2001
Export Citation:
Assignee:
UNIV TECHNOLOGIES INT (CA)
PON RICHARD T (CA)
SANGHVI YOGESH (US)
YU SHUYUAN (CA)
PON RICHARD T (CA)
SANGHVI YOGESH (US)
YU SHUYUAN (CA)
International Classes:
C07H21/00; (IPC1-7): C07H21/00
Domestic Patent References:
| WO1993020092A1 | 1993-10-14 | |||
| WO1997023497A1 | 1997-07-03 | |||
| WO2002020537A2 | 2002-03-14 |
Foreign References:
| EP0067597A1 | 1982-12-22 |
Other References:
MERRIFIELD R.B.: "SOLID PHASE PEPTIDE SYNTHESIS. I. THE SYNTHESIS OF A TETRAPEPTIDE", J. AM.CHEM. SOC., vol. 85, 1963, pages 2149 - 2154, XP000994867
FOURNIER, A. ET AL.: "APPLICATIONS OF BOP REAGENT IN SOLID PHASE PEPTIDE SYNTHESIS", INTERN. J. PEPT. & PROT. RES., vol. 33, no. 2, 1989, pages 133 - 139, XP000007142
HARDY, P.M. ET AL.: "REAGENTS FOR THE PREPARATION OF TWO OLIGONUCLEOTIDES PER SYNTHESIS", NUCLEIC ACIDS RESEARCH, vol. 22, no. 15, 1994, pages 2998 - 3004, XP002196437
PON, R. T. ET AL: "Multiple oligonucleotide synthesis in tandem on solid-phase supports for small and large scale synthesis", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS (2001), 20(4-7), 985-989, XP002196438
FOURNIER, A. ET AL.: "APPLICATIONS OF BOP REAGENT IN SOLID PHASE PEPTIDE SYNTHESIS", INTERN. J. PEPT. & PROT. RES., vol. 33, no. 2, 1989, pages 133 - 139, XP000007142
HARDY, P.M. ET AL.: "REAGENTS FOR THE PREPARATION OF TWO OLIGONUCLEOTIDES PER SYNTHESIS", NUCLEIC ACIDS RESEARCH, vol. 22, no. 15, 1994, pages 2998 - 3004, XP002196437
PON, R. T. ET AL: "Multiple oligonucleotide synthesis in tandem on solid-phase supports for small and large scale synthesis", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS (2001), 20(4-7), 985-989, XP002196438
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