Title:
STAVUDINE POLYMORPHIC FORM 1 PROCESS
Document Type and Number:
WIPO Patent Application WO2002020538
Kind Code:
A3
Abstract:
A process for the formation of Stavudine Polymorphic Form I from a mixture comprising Polymorphic Form I and at least one of Polymorphic Forms II and III is disclosed using the technique of Solution-Enhanced Dispersion by Supercritical Fluids (SEDS). A solution of the mixture in isopropyl alcohol/water is introduced into a particle formation vessel with a supercritical fluid under controlled temperature and pressure whereby the supercritical fluid substantially simultaneously disperses and extracts the solvent from the solution forming discrete particles of Stavudine Polymorphic Form I. A preferred supercritical fluid is carbon dioxide.
Inventors:
BRISTOW SIMON CRAWFORD
COCKS PHILIP MICHAEL
HARLAND RONALD
GANDHI RAJESH B
COCKS PHILIP MICHAEL
HARLAND RONALD
GANDHI RAJESH B
Application Number:
PCT/US2001/026225
Publication Date:
May 30, 2002
Filing Date:
August 22, 2001
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
International Classes:
A61P31/18; C07H1/06; C07H19/06; (IPC1-7): C07H19/06; C07H1/06; A61K31/7072; A61P31/18
Foreign References:
| US5608048A | 1997-03-04 | |||
| US5851453A | 1998-12-22 | |||
| EP0653435A1 | 1995-05-17 | |||
| EP0735044A1 | 1996-10-02 |
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