PROCESS FOR PRODUCING OPTICALLY ACTIVE IMIDAZOLE COMPOUNDS, INTERMEDIATES FOR SYNTHESIZING THE SAME, AND PROCESS FOR PRODUCING THE SAME

Title:

PROCESS FOR PRODUCING OPTICALLY ACTIVE IMIDAZOLE COMPOUNDS, INTERMEDIATES FOR SYNTHESIZING THE SAME, AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/1998/032740

Kind Code:

A1

Abstract:

A process for producing optically active 4-[$g(a)-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid or pharmacologically acceptable salts thereof which comprises optically resolving compounds represented by general formula (I) by fractional crystallization to give the optically active isomer thereof and then hydrolyzing the isomer, wherein each symbol is as defined in the specification. This process can provide a resolution method useful for industrially mass-producing the optically active isomer of 4-[$g(a)-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid which is useful as a thromboxane synthesis inhibitor and a preventive/remedy for diabetic complications.

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Inventors:

KAWASAKI KAZUYUKI (JP)
KOBAYASHI HARUHITO (JP)
EHARA SYUJI (JP)
SATO HIDEAKI (JP)

Application Number:

PCT/JP1998/000150

Publication Date:

July 30, 1998

Filing Date:

January 14, 1998

Export Citation:

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Assignee:

YOSHITOMI PHARMACEUTICAL (JP)
KAWASAKI KAZUYUKI (JP)
KOBAYASHI HARUHITO (JP)
EHARA SYUJI (JP)
SATO HIDEAKI (JP)

International Classes:

A61K31/415; A61P3/10; A61P43/00; C07D233/58; C07D233/60; C07D521/00; (IPC1-7): C07D233/60

Foreign References:

JPH02215771A	1990-08-28
JPS5770884A	1982-05-01

Other References: