Title:
PROCESS FOR THE PRODUCTION OF D-AMINO ACIDS
Document Type and Number:
WIPO Patent Application WO2005017171
Kind Code:
A3
Abstract:
The present invention focuses on a process for the production of enantiopure D-amino acids. In particular, a mixture of D- and L-amino acids is treated with an enzymatic reaction system in such a way that the L-form of the amino acid is removed from the system, leaving only the D-form of the amino acid. The present invention also provides a reaction system that operates in such a way and a whole-cell catalyst that can be used for the process according to the invention.
Inventors:
HUMMEL WERNER (DE)
GEUEKE BIRGIT (CH)
KUZU MUTLU (DE)
GROEGER HARALD (DE)
GEUEKE BIRGIT (CH)
KUZU MUTLU (DE)
GROEGER HARALD (DE)
Application Number:
PCT/EP2004/009000
Publication Date:
June 23, 2005
Filing Date:
August 12, 2004
Export Citation:
Assignee:
DEGUSSA (DE)
HUMMEL WERNER (DE)
GEUEKE BIRGIT (CH)
KUZU MUTLU (DE)
GROEGER HARALD (DE)
HUMMEL WERNER (DE)
GEUEKE BIRGIT (CH)
KUZU MUTLU (DE)
GROEGER HARALD (DE)
International Classes:
C12P13/04; C12P41/00; (IPC1-7): C12P13/04; C12P41/00
Domestic Patent References:
| WO1995011296A1 | 1995-04-27 |
Foreign References:
| EP0919630A1 | 1999-06-02 | |||
| US5416019A | 1995-05-16 | |||
| EP0692538A2 | 1996-01-17 |
Other References:
LAUMEN K. ET AL: "Enzyme-assisted preparation of D-tert.-leucine", BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 65, no. 9, September 2001 (2001-09-01), pages 1977 - 1980, XP002323144, ISSN: 0916-8451
BOMMARIUS A. S. ET AL: "Comparison of different chemoenzymatic process routes to enantiomerically pure amino acids", CHIMIA, vol. 55, no. 1-2, 2001, pages 50 - 59, XP001204656
DRAUZ K. H.: "Chiral amino acids. A versatile tool in the synthesis of pharmaceuticals and fine chemicals", CHIMIA, vol. 51, no. 6, 1997, pages 310 - 314, XP001204657
DATABASE WPI Section Ch Week 197829, Derwent World Patents Index; Class B05, AN 1978-52387A, XP002323148
BOMMARIUS A.S. ET AL: "Some new developments in reductive amination with cofactor regeneration", BIOCATALYSIS, vol. 10, no. 1-4, 1994, pages 37 - 47, XP008045061
KRIX G ET AL: "Enzymatic reduction of alpha-keto acids leading to l-amino acids, d- or l-hydroxy acids", JOURNAL OF BIOTECHNOLOGY, vol. 53, no. 1, 28 February 1997 (1997-02-28), pages 29 - 39, XP004075445, ISSN: 0168-1656
KIBA N. ET AL: "Chemiluminometric branched chain amino acids determination with immobilized enzymes by flow-injection analysis", ANALYTICA CHIMICA ACTA, vol. 375, no. 1-2, 27 November 1998 (1998-11-27), pages 65 - 70, XP002323146, ISSN: 0003-2670
KIBA N. ET AL: "Postcolumn co-immobilized leucine dehydrogenase-NADH oxidase reactor for the determination of branched-chain amino acids by high-performance liquid chromatography with chemiluminescence detection", JOURNAL OF CHROMATOGRAPHY A, vol. 724, no. 1, 16 February 1996 (1996-02-16), pages 354 - 357, XP004039579, ISSN: 0021-9673
HUMMEL W. ET AL: "An efficient and selective enzymatic oxidation system for the synthesis of enantiomerically pure D-tert-leucine.", ORGANIC LETTERS, vol. 5, no. 20, 2 October 2003 (2003-10-02), pages 3649 - 3650, XP002323147, ISSN: 1523-7060
BOMMARIUS A. S. ET AL: "Comparison of different chemoenzymatic process routes to enantiomerically pure amino acids", CHIMIA, vol. 55, no. 1-2, 2001, pages 50 - 59, XP001204656
DRAUZ K. H.: "Chiral amino acids. A versatile tool in the synthesis of pharmaceuticals and fine chemicals", CHIMIA, vol. 51, no. 6, 1997, pages 310 - 314, XP001204657
DATABASE WPI Section Ch Week 197829, Derwent World Patents Index; Class B05, AN 1978-52387A, XP002323148
BOMMARIUS A.S. ET AL: "Some new developments in reductive amination with cofactor regeneration", BIOCATALYSIS, vol. 10, no. 1-4, 1994, pages 37 - 47, XP008045061
KRIX G ET AL: "Enzymatic reduction of alpha-keto acids leading to l-amino acids, d- or l-hydroxy acids", JOURNAL OF BIOTECHNOLOGY, vol. 53, no. 1, 28 February 1997 (1997-02-28), pages 29 - 39, XP004075445, ISSN: 0168-1656
KIBA N. ET AL: "Chemiluminometric branched chain amino acids determination with immobilized enzymes by flow-injection analysis", ANALYTICA CHIMICA ACTA, vol. 375, no. 1-2, 27 November 1998 (1998-11-27), pages 65 - 70, XP002323146, ISSN: 0003-2670
KIBA N. ET AL: "Postcolumn co-immobilized leucine dehydrogenase-NADH oxidase reactor for the determination of branched-chain amino acids by high-performance liquid chromatography with chemiluminescence detection", JOURNAL OF CHROMATOGRAPHY A, vol. 724, no. 1, 16 February 1996 (1996-02-16), pages 354 - 357, XP004039579, ISSN: 0021-9673
HUMMEL W. ET AL: "An efficient and selective enzymatic oxidation system for the synthesis of enantiomerically pure D-tert-leucine.", ORGANIC LETTERS, vol. 5, no. 20, 2 October 2003 (2003-10-02), pages 3649 - 3650, XP002323147, ISSN: 1523-7060
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