PROCESS FOR THE PURIFICATION OF RECOMBINANT POLYPEPTIDES

WIPO Patent Application WO2005017174

A3

This invention relates to a method for purification of a recombinant polypeptide of interest, which polypeptide upon expression has been secreted into the periplasm of a transformed host cell.

WO/1998/000542	METHODS FOR ADMINISTRATION OF RECOMBINANT GENE DELIVERY VEHICLES FOR TREATMENT OF HEMOPHILIA
WO/2002/095067	INTERFERON &agr -14 POLYMORPHISM
WO2001057217	EXPRESSION AND SECRETION VECTOR FOR HUMAN INTERFERON ALPHA AND PROCESS FOR PRODUCING HUMAN INTERFERON ALPHA BY EMPLOYING SAME

STEMPFER GUENTER (AT)
ALLIGER PETER (AT)
PALMA NORBERT (AT)

PCT/EP2004/009055

August 18, 2005

August 12, 2004

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SANDOZ AG (CH)
STEMPFER GUENTER (AT)
ALLIGER PETER (AT)
PALMA NORBERT (AT)

C07K14/56; C12N1/06; C12P21/00; C12P21/02; (IPC1-7): C12P21/00; C07K14/56

WO1989000201A1	1989-01-12
WO2003004599A2	2003-01-16

HART R A ET AL: "LARGE SCALE, IN SITU ISOLATION OF PERIPLASMIC IGF-I FROM E. COLI", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 12, November 1994 (1994-11-01), pages 1113 - 1117, XP001153305, ISSN: 0733-222X
FRENCH C ET AL: "DEVELOPMENT OF A SIMPLE METHOD FOR THE RECOVERY OF RECOMBINANT PROTEINS FROM THE ESCHERICHIA COLI PERIPLASM", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 19, no. 5, 1996, pages 332 - 338, XP000886796, ISSN: 0141-0229
DALMORA S ET AL: "Analysis of recombinant human growth hormone directly in osmotic shock fluids", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 782, no. 2, 10 October 1997 (1997-10-10), pages 199 - 210, XP004096275, ISSN: 0021-9673

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