Title:
PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE ERYTHRO-β-AMINO ALCOHOL
Document Type and Number:
WIPO Patent Application WO/2007/004639
Kind Code:
A1
Abstract:
Disclosed is a process for producing an erythro-β-amino alcohol compound, which is an optically active intermediate useful in the production of a pharmaceutical, in a simple manner and with good efficiency. An enantiometric mixture of an α-amino ketone compound or a salt thereof is reacted with a cell of at least one microorganism selected from microorganisms belonging to the genera Nocardia, Rhodococcus, Kuraishia, Rhodotorula, Sporidiobolus, Pichia and Candida, a product of the cell given by any treatment or a culture of the cell to produce a corresponding optically active erythro-β-amino alcohol compound at a high chemical purity, a high optical purity, a high optical yield and a high conversion rate. Thus, an excellent technique for production of a pharmaceutical can be provided.
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Inventors:
SAKAMOTO KEIJI (JP)
KITA SHINJI (JP)
TOKAI HIDEAKI (JP)
SUMI KOICHI (JP)
KITA SHINJI (JP)
TOKAI HIDEAKI (JP)
SUMI KOICHI (JP)
Application Number:
PCT/JP2006/313293
Publication Date:
January 11, 2007
Filing Date:
July 04, 2006
Export Citation:
Assignee:
DAIICHI FINE CHEM CO LTD (JP)
SAKAMOTO KEIJI (JP)
KITA SHINJI (JP)
TOKAI HIDEAKI (JP)
SUMI KOICHI (JP)
SAKAMOTO KEIJI (JP)
KITA SHINJI (JP)
TOKAI HIDEAKI (JP)
SUMI KOICHI (JP)
International Classes:
C12P13/00; C07B53/00; C07C227/02; C07C229/34; C12R1/01; C12R1/365; C12R1/645
Domestic Patent References:
| WO2001073100A1 | 2001-10-04 | |||
| WO1999005090A1 | 1999-02-04 |
Attorney, Agent or Firm:
MIZUNO, Akinobu (22-12 Maruyama-ch, Shibuya-ku Tokyo, JP)
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