Title:
PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE PHOSPHOROUS COMPOUND
Document Type and Number:
WIPO Patent Application WO/2008/032531
Kind Code:
A1
Abstract:
Disclosed is a process for producing an optically active phosphorous compound
having an R- or S-type absolute configuration on phosphorous in a simple manner
and at high efficiency, while avoiding racemization. An optically active phosphorus
compound having an R- or S-type absolute configuration on phosphorous represented
by the general formula (III) can be produced by reacting an optically active phosphorous
compound having an R- or S-type absolute configuration on phosphorous represented
by the general formula (I) with a metal compound represented by the general formula
(II) and water. (I) wherein R1 represents a hydrogen atom, analkyl
group, a cycloalkyl group, an aralkyl group or an aryl group; and R2
represents a hydrogen, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl
group, alkenyl group, an alkoxy group, an aryloxy group, a heterocyclic ring
residue or a silyl-containing group. R3M (II) wherein R3
is the same as R2; and M represents a lithium or magnesium halide MgX
(X=Cl, Br or I). (III) wherein R2 and R3 are as defined above.
Inventors:
HAN LI-BIAO (JP)
XU QING (JP)
XU QING (JP)
Application Number:
PCT/JP2007/066092
Publication Date:
March 20, 2008
Filing Date:
August 20, 2007
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
HAN LI-BIAO (JP)
XU QING (JP)
HAN LI-BIAO (JP)
XU QING (JP)
International Classes:
C07F9/53; C07B53/00; C07F9/58; C07F9/6553; C07F7/08
Foreign References:
| JPH0586082A | 1993-04-06 | |||
| JPH032190A | 1991-01-08 |
Other References:
LEYRIS A. ET AL.: "Enantioselective synthesis of secondary phosphine oxides from (Rp)-(-)-methyl hydrogenophenylphosphine", TETRAHEDRON LETTERS, vol. 48, no. 30, 30 July 2007 (2007-07-30), pages 5247 - 5250, XP022132319
OLSZEWSKI T.K. ET AL.: "Synthesis of thiazole aminophosphine oxides, aminophosphonic and aminophosphonic acids and Cu(II) binding abilities of thiazole aminophosphonic acids", TETRAHEDRON, vol. 62, no. 10, 6 March 2006 (2006-03-06), pages 2183 - 2189, XP005290290
SHIOJI K. ET AL.: "Synthesis of 5-(Alkylphenylphosphoryl)-5-methyl-3,4-dihydro-2H-pyrroline N-Oxide as a New Spin Trapping Reagent", CHEMISTRY LETTERS, vol. 32, no. 7, 2003, pages 604 - 605, XP003019991
OLSZEWSKI T.K. ET AL.: "Synthesis of thiazole aminophosphine oxides, aminophosphonic and aminophosphonic acids and Cu(II) binding abilities of thiazole aminophosphonic acids", TETRAHEDRON, vol. 62, no. 10, 6 March 2006 (2006-03-06), pages 2183 - 2189, XP005290290
SHIOJI K. ET AL.: "Synthesis of 5-(Alkylphenylphosphoryl)-5-methyl-3,4-dihydro-2H-pyrroline N-Oxide as a New Spin Trapping Reagent", CHEMISTRY LETTERS, vol. 32, no. 7, 2003, pages 604 - 605, XP003019991
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