Title:
PRODUCTION SYSTEM AND PRODUCTION METHOD FOR FLAVAN OLIGOMER
Document Type and Number:
WIPO Patent Application WO/2023/171250
Kind Code:
A1
Abstract:
The present invention provides a production system and a production method for a flavan oligomer, the system and method being capable of efficiently synthesizing, at high yield, a flavan oligomer in which flavan derivatives are bonded to each other at a desired polymerization degree. A production system (1) for a flavan oligomer comprises: a microreactor (106) in which a first fluid introduced from one inlet and a second fluid introduced from the other inlet are mixed in a flow path; a first container (101) in which the first fluid is prepared; a second container (102) in which the second fluid is prepared; and a recovery container (103) for recovering the generated fluid, wherein the first fluid is a liquid containing a flavan derivative having a flavan skeleton, the second fluid is a liquid containing a Lewis acid, and the generated fluid is recovered into a liquid containing a base. The production method for a flavan oligomer comprises: mixing a first fluid with a second fluid in a microreactor; activating a flavan derivative of the first fluid with a Lewis acid of the second fluid; starting the reaction between an activated flavan derivative and a flavan derivative acting as a nucleophilic body; and stopping the reaction with a base.
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Inventors:
ASANO YUKAKO (JP)
TAGAMI MASASHI (JP)
OHMORI KEN (JP)
NARITA NAOKI (JP)
TAGAMI MASASHI (JP)
OHMORI KEN (JP)
NARITA NAOKI (JP)
Application Number:
PCT/JP2023/004768
Publication Date:
September 14, 2023
Filing Date:
February 13, 2023
Export Citation:
Assignee:
HITACHI PLANT SERVICES CO LTD (JP)
International Classes:
C07D311/62; A61K31/352; A61P31/04; A61P35/00; A61P39/06; B01J19/00; B81B1/00; C08G61/12
Domestic Patent References:
| WO2021192573A1 | 2021-09-30 | |||
| WO2006043642A1 | 2006-04-27 |
Foreign References:
| JP2011522034A | 2011-07-28 | |||
| JP2017001982A | 2017-01-05 | |||
| JP2019151583A | 2019-09-12 | |||
| JP2019042713A | 2019-03-22 |
Other References:
JENS WEGNER; SASCHA CEYLAN; CARSTEN FRIESE; ANDREAS KIRSCHNING: "Inductively Heated Oxides Inside Microreactors – Facile Oxidations under Flow Conditions", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2010, no. 23, 13 July 2010 (2010-07-13), DE , pages 4372 - 4375, XP072112901, ISSN: 1434-193X, DOI: 10.1002/ejoc.201000628
FURUSAWA RYUTA, TAKASAKI MIKIHIRO, SAWADA TSUYOSHI, KUWAHARA YUTAKA, SHOSENJI HIDETO: "3PC-094: Syntheses of macrocyclic metacyclophanes using capillary microreactor", PROCEEDINGS OF THE 84TH ANNUAL SPRING MEETING OF CHEMICAL SOCIETY OF JAPAN (CSJ) ; TOKYO, JAPAN; MARCH 26-29, 2004, vol. 84, no. 2, 11 March 2004 (2004-03-11) - 29 March 2004 (2004-03-29), pages 1418, XP009548892
MISA KAWASE, KYOSUKE MATSUOKA, OSAMU SHIMOMURA, ATSUSHI OHTAKA: "B204-3vn-07 Suzuki-Miyaura Cross-Coupling Reaction with Potassium Aryltrifluoroborates in Water using Recyclable Nanoparticle Catalyst", PROCEEDINGS OF THE 102ND ANNUAL SPRING MEETING OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); [ONLINE MEETING]; MARCH 23-26, 2022, vol. 102, 1 March 2022 (2022-03-01) - 26 March 2022 (2022-03-26), pages B204 - 3vn, XP009548891
FURUSAWA RYUTA, TAKASAKI MIKIHIRO, SAWADA TSUYOSHI, KUWAHARA YUTAKA, SHOSENJI HIDETO: "3PC-094: Syntheses of macrocyclic metacyclophanes using capillary microreactor", PROCEEDINGS OF THE 84TH ANNUAL SPRING MEETING OF CHEMICAL SOCIETY OF JAPAN (CSJ) ; TOKYO, JAPAN; MARCH 26-29, 2004, vol. 84, no. 2, 11 March 2004 (2004-03-11) - 29 March 2004 (2004-03-29), pages 1418, XP009548892
MISA KAWASE, KYOSUKE MATSUOKA, OSAMU SHIMOMURA, ATSUSHI OHTAKA: "B204-3vn-07 Suzuki-Miyaura Cross-Coupling Reaction with Potassium Aryltrifluoroborates in Water using Recyclable Nanoparticle Catalyst", PROCEEDINGS OF THE 102ND ANNUAL SPRING MEETING OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); [ONLINE MEETING]; MARCH 23-26, 2022, vol. 102, 1 March 2022 (2022-03-01) - 26 March 2022 (2022-03-26), pages B204 - 3vn, XP009548891
Attorney, Agent or Firm:
ISONO INTERNATIONAL PATENT OFFICE, P.C. (JP)
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