Title:
PRODUCTION OF USEFUL PROTEIN SUCH AS ANTIBODY HAVING MODIFIED SUGAR CHAIN IN EGG YOLK OF TRANSGENIC CHICKEN
Document Type and Number:
WIPO Patent Application WO/2008/018562
Kind Code:
A1
Abstract:
Every method for producing an exogenous protein has been disclosed so far, however, an original effect could not be obtained due to a difference in the sugar-chain structure to be modified in some proteins. In order to resolve this problem, a method for producing an exogenous protein having a sugar-chain structure equivalent or similar to that of human is needed. Because an exogenous protein accumulated in egg yolk of a transgenic bird, particularly chicken has a sugar-chain structure equivalent or similar to that of human, it becomes possible to produce a large amount of a human pharmaceutical protein with a high bioactivity by employing this.
Inventors:
IIJIMA SHINJI (JP)
KAMIHIRA MASAMICHI (JP)
NISHIJIMA KENICHI (JP)
YAMASHITA TAKASHI (JP)
KAMIHIRA MASAMICHI (JP)
NISHIJIMA KENICHI (JP)
YAMASHITA TAKASHI (JP)
Application Number:
PCT/JP2007/065655
Publication Date:
February 14, 2008
Filing Date:
August 09, 2007
Export Citation:
Assignee:
KANEKA CORP (JP)
UNIV NAGOYA (JP)
IIJIMA SHINJI (JP)
KAMIHIRA MASAMICHI (JP)
NISHIJIMA KENICHI (JP)
YAMASHITA TAKASHI (JP)
UNIV NAGOYA (JP)
IIJIMA SHINJI (JP)
KAMIHIRA MASAMICHI (JP)
NISHIJIMA KENICHI (JP)
YAMASHITA TAKASHI (JP)
International Classes:
C07K19/00; C12N15/09; C12P21/00
Domestic Patent References:
| WO2004016081A1 | 2004-02-26 | |||
| WO2006035687A1 | 2006-04-06 |
Other References:
KAMIHIRA M. ET AL.: "High-Level Expression of Single-Chain Fv-Fc Fusion Protein in Serum and Egg White of Genetically Manipulated Chickens by Using a Retroviral Vector", JOURNAL OF VIROLOGY, vol. 79, no. 17, 2005, pages 10864 - 10874, XP003020744
RAJU T.S. ET AL.: "Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recomninant glycoprotein therapeutics", GLYCOBIOLOGY, vol. 10, no. 5, 2000, pages 477 - 486, XP002964086
RAJU T.S. ET AL.: "Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recomninant glycoprotein therapeutics", GLYCOBIOLOGY, vol. 10, no. 5, 2000, pages 477 - 486, XP002964086
Attorney, Agent or Firm:
YASUTOMI, Yasuo et al. (5-36 Miyahara 3-chome, Yodogawa-ku, Osaka-sh, Osaka 03, JP)
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