Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR RETINAL DISEASE CAUSED BY RETINAL PIGMENT EPITHELIUM DISORDER
Document Type and Number:
WIPO Patent Application WO/2015/029948
Kind Code:
A1
Abstract:
Provided is a prophylactic or therapeutic agent for a retinal disease, said disease being caused by retinal pigment epithelium (RPE) disorder and not accompanying choroidal neovascularization, which comprises as an active ingredient a drug having a preventive effect against sodium iodate-induced RPE cell death.
Inventors:
NIWA SHIN-ICHIRO (JP)
HAYASHI HIDEMI (JP)
HAYASHI HIDEMI (JP)
Application Number:
PCT/JP2014/072161
Publication Date:
March 05, 2015
Filing Date:
August 25, 2014
Export Citation:
Assignee:
LINK GENOMICS INC (JP)
International Classes:
A61K45/00; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K31/192; A61K31/196; A61K31/197; A61K31/395; A61K31/404; A61K31/4184; A61K31/4439; A61K31/496; A61K31/506; A61P27/02
Domestic Patent References:
| WO2012062834A1 | 2012-05-18 |
Foreign References:
| JP2011006406A | 2011-01-13 | |||
| JP2011520788A | 2011-07-21 | |||
| US20110269807A1 | 2011-11-03 | |||
| JP2009507770A | 2009-02-26 | |||
| JP2013525398A | 2013-06-20 |
Other References:
TOKUHARU OYA ET AL.: "Momaku Shikiso Henseisho no Seiin to Chiryo XI alpha-Methyldopa no Rinsho Seiseki", JAPANESE JOURNAL OF CLINICAL OPHTHALMOLOGY, vol. 17, no. 3, 1963, pages 248 - 254
STEINLE,N.C. ET AL.: "Oral rifampin utilisation for the treatment of chronic multifocal central serous retinopathy", THE BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 96, no. 1, 2012, pages 10 - 13
TAM,L.C.S. ET AL.: "Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90", HUMAN MOLECULAR GENETICS, vol. 19, no. 22, 2010, pages 4421 - 4436
UMAZUME,K. ET AL.: "Inhibition of PVR with a tyrosine kinase inhibitor, dasatinib, in the swine", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 54, no. 2, February 2013 (2013-02-01), pages 1150 - 1159
TOKUHARU OYA: "Momaku Shikiso Henseisho no Seiin to Chiryo X Jikken Henseisho ni Okeru Catecholamine Kanren Busshitsu no ERG ni Oyobosu Eikyo", JOURNAL OF JAPANESE OPHTHALMOLOGICAL SOCIETY, vol. 66, no. 12, 1962, pages 1493 - 1500
TARABISHY,A.B. ET AL.: "Central serous retinopathy", ARTHRITIS CARE & RESEARCH, vol. 63, no. 8, 2011, pages 1075 - 1082
HIROSHI SAWA ET AL.: "Proliferative Vitreoretinopathy : Retinal Detachment", JOURNAL OF THE EYE, vol. 16, no. 1, 1999, pages 33 - 41
WANG,Y. ET AL.: "The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment", EYE, vol. 25, no. 2, 2011, pages 127 - 139
HIROYUKI SHIMADA ET AL.: "Effects of on anti- prostaglandin agent added to the irrigation solution on macular edema in monkey eyes induced by pars plana vitrectomy", JOURNAL OF JAPANESE OPHTHALMOLOGICAL SOCIETY, vol. 91, no. 6, 1987, pages 647 - 656
POURGHOLAMI,M.H.: "Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 397, no. 4, 2010, pages 729 - 734
UEDA,K. ET AL.: "Protective effects of TGF-beta inhibitors in a rat model of NMDA-induced retinal degeneration", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 699, no. 1-3, January 2013 (2013-01-01), pages 188 - 193
STEINLE,N.C. ET AL.: "Oral rifampin utilisation for the treatment of chronic multifocal central serous retinopathy", THE BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 96, no. 1, 2012, pages 10 - 13
TAM,L.C.S. ET AL.: "Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90", HUMAN MOLECULAR GENETICS, vol. 19, no. 22, 2010, pages 4421 - 4436
UMAZUME,K. ET AL.: "Inhibition of PVR with a tyrosine kinase inhibitor, dasatinib, in the swine", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 54, no. 2, February 2013 (2013-02-01), pages 1150 - 1159
TOKUHARU OYA: "Momaku Shikiso Henseisho no Seiin to Chiryo X Jikken Henseisho ni Okeru Catecholamine Kanren Busshitsu no ERG ni Oyobosu Eikyo", JOURNAL OF JAPANESE OPHTHALMOLOGICAL SOCIETY, vol. 66, no. 12, 1962, pages 1493 - 1500
TARABISHY,A.B. ET AL.: "Central serous retinopathy", ARTHRITIS CARE & RESEARCH, vol. 63, no. 8, 2011, pages 1075 - 1082
HIROSHI SAWA ET AL.: "Proliferative Vitreoretinopathy : Retinal Detachment", JOURNAL OF THE EYE, vol. 16, no. 1, 1999, pages 33 - 41
WANG,Y. ET AL.: "The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment", EYE, vol. 25, no. 2, 2011, pages 127 - 139
HIROYUKI SHIMADA ET AL.: "Effects of on anti- prostaglandin agent added to the irrigation solution on macular edema in monkey eyes induced by pars plana vitrectomy", JOURNAL OF JAPANESE OPHTHALMOLOGICAL SOCIETY, vol. 91, no. 6, 1987, pages 647 - 656
POURGHOLAMI,M.H.: "Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 397, no. 4, 2010, pages 729 - 734
UEDA,K. ET AL.: "Protective effects of TGF-beta inhibitors in a rat model of NMDA-induced retinal degeneration", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 699, no. 1-3, January 2013 (2013-01-01), pages 188 - 193
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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