Title:
PROPHYLACTIC OR THERAPEUTIC COMPOSITION FOR DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME
Document Type and Number:
WIPO Patent Application WO/2022/185742
Kind Code:
A1
Abstract:
A prophylactic or therapeutic composition for disseminated intravascular coagulation syndrome, the composition comprising, as an active ingredient, at least one selected from adenosine A2a receptor antagonists and dopamine D2-like receptor agonists.
Inventors:
MATSUSHITA SHO (JP)
KAWANO MASAAKI (JP)
TOKANO MIEKO (JP)
TAKAGI RIE (JP)
MAESAKI SHIGEFUMI (JP)
TARUMOTO NORIHITO (JP)
KAWANO MASAAKI (JP)
TOKANO MIEKO (JP)
TAKAGI RIE (JP)
MAESAKI SHIGEFUMI (JP)
TARUMOTO NORIHITO (JP)
Application Number:
PCT/JP2022/001353
Publication Date:
September 09, 2022
Filing Date:
January 17, 2022
Export Citation:
Assignee:
UNIV SAITAMA MEDICAL (JP)
International Classes:
A61K45/00; A61K31/381; A61K31/404; A61K31/428; A61K31/473; A61K31/4745; A61K31/4985; A61K31/506; A61K31/519; A61K31/522; A61K31/55; A61P7/02; A61P31/00; A61P31/14; A61P43/00
Domestic Patent References:
| WO2014123186A1 | 2014-08-14 | |||
| WO2018221562A1 | 2018-12-06 |
Foreign References:
| JP2002527479A | 2002-08-27 |
Other References:
MATSUYAMA, TOSHIYUKI AND 2 OTHERS: "Inhibition of neutrophilic inflammation by dopamine D2-like receptor agonist", JOURNAL OF JAPAN SOCIETY OF IMMUNOLOGY & ALLERGOLOGY IN OTOLARYNGOLOGY, vol. 36, no. 2, 1 January 2018 (2018-01-01) - 24 February 2018 (2018-02-24), pages 93 - 94, XP009539584, ISSN: 0913-0691, DOI: 10.5648/jjiao.36.81
BORGES LEANDRO, PITHON-CURI TANIA CRISTINA, CURI RUI, HATANAKA ELAINE: "COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps", MEDIATORS OF INFLAMMATION., RAPID COMMUNICATION OF OXFORD LTD., OXFORD., GB, vol. 2020, 2 December 2020 (2020-12-02), GB , pages 1 - 7, XP055963925, ISSN: 0962-9351, DOI: 10.1155/2020/8829674
HIROSE TOMOYA, TASAKI OSAMU, OGURA HIROSHI, SHIMAZU TAKESHI: "Disseminated intravascular coagulation (DIC) and NETs", THROMBOSIS MEDICINE, vol. 9, no. 4, 1 January 2019 (2019-01-01), pages 11 (291) - 15 (295), XP009539554, ISSN: 2186-0327
ELZUPIR AMIN O.: "Caffeine and caffeine-containing pharmaceuticals as promising inhibitors for 3-chymotrypsin-like protease of SARS-CoV-2", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 40, no. 5, 24 March 2022 (2022-03-24), US , pages 2113 - 2120, XP055963927, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1835732
ALI RAMADAN A., GANDHI ALEX A., MENG HE, YALAVARTHI SRILAKSHMI, VREEDE ANDREW P., ESTES SHANEA K., PALMER OLIVIA R., BOCKENSTEDT P: "Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055963929, DOI: 10.1038/s41467-019-09801-x
KAI XU, ERIC SHIN, LANFANG WANG, JULINE DEPPEN, REBECCA LEVIT: "Abstract 251: The Role of Adenosine Derived From Mesenchymal Stromal Cell on Neutrophil Extracellular Trap Formation in Myocardial Ischemia Reperfusion", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE GRUNDE AND STRATTON , BALTIMORE, US, vol. 123, no. Suppl. 1, 3 August 2018 (2018-08-03) - 2 August 2018 (2018-08-02), US , pages 251, XP009539589, ISSN: 0009-7330, DOI: 10.1161/res.123.suppl_1.251
BORGES LEANDRO, PITHON-CURI TANIA CRISTINA, CURI RUI, HATANAKA ELAINE: "COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps", MEDIATORS OF INFLAMMATION., RAPID COMMUNICATION OF OXFORD LTD., OXFORD., GB, vol. 2020, 2 December 2020 (2020-12-02), GB , pages 1 - 7, XP055963925, ISSN: 0962-9351, DOI: 10.1155/2020/8829674
HIROSE TOMOYA, TASAKI OSAMU, OGURA HIROSHI, SHIMAZU TAKESHI: "Disseminated intravascular coagulation (DIC) and NETs", THROMBOSIS MEDICINE, vol. 9, no. 4, 1 January 2019 (2019-01-01), pages 11 (291) - 15 (295), XP009539554, ISSN: 2186-0327
ELZUPIR AMIN O.: "Caffeine and caffeine-containing pharmaceuticals as promising inhibitors for 3-chymotrypsin-like protease of SARS-CoV-2", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 40, no. 5, 24 March 2022 (2022-03-24), US , pages 2113 - 2120, XP055963927, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1835732
ALI RAMADAN A., GANDHI ALEX A., MENG HE, YALAVARTHI SRILAKSHMI, VREEDE ANDREW P., ESTES SHANEA K., PALMER OLIVIA R., BOCKENSTEDT P: "Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055963929, DOI: 10.1038/s41467-019-09801-x
KAI XU, ERIC SHIN, LANFANG WANG, JULINE DEPPEN, REBECCA LEVIT: "Abstract 251: The Role of Adenosine Derived From Mesenchymal Stromal Cell on Neutrophil Extracellular Trap Formation in Myocardial Ischemia Reperfusion", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE GRUNDE AND STRATTON , BALTIMORE, US, vol. 123, no. Suppl. 1, 3 August 2018 (2018-08-03) - 2 August 2018 (2018-08-02), US , pages 251, XP009539589, ISSN: 0009-7330, DOI: 10.1161/res.123.suppl_1.251
Attorney, Agent or Firm:
ITOH Tadashige et al. (JP)
Download PDF: