Title:
PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALEROAMIDES FOR THE SYNTHESIS OF EPOTHILONE AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO2003014063
Kind Code:
A3
Abstract:
The invention relates to novel protected 3.5-dihydroxy-2.2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and to a method for the production and e use of said novel compounds in the production of epothilones or epothilone derivatives.
Inventors:
WESTERMANN JUERGEN
PETROV ORLIN
PLATZEK JOHANNES
PETROV ORLIN
PLATZEK JOHANNES
Application Number:
PCT/EP2002/008726
Publication Date:
May 01, 2003
Filing Date:
August 05, 2002
Export Citation:
Assignee:
SCHERING AG (DE)
International Classes:
A61K31/335; A61P35/00; C07B61/00; C07C231/12; C07C231/16; C07C231/18; C07C235/06; C07C235/16; C07C235/74; C07D319/06; C07D319/08; C07D493/02; C07D493/04; C07F7/18; C12P13/02; C12P41/00; (IPC1-7): C07C235/06; C07D319/06; C07F7/18; C07D319/08; C07C235/16; C07C231/14; C07C45/54
Domestic Patent References:
| WO2000058254A1 | 2000-10-05 |
Other References:
R. E. TAYLOR, YUE CHEN: "Total Synthesis of Epothilones B and D", ORGANIC LETTERS, vol. 3, no. 14, 2001, pages 2221 - 4, XP002227325
A. FÜRSTNER ET AL.: "Concise total synthesis of epothilone A and C based on alkyne metathesis", CHEM. COMMUN., 2001, pages 1057 - 9, XP002227326
J. MULZER ET AL.: "Total Synthesis of Epothilones B and D", J. ORG. CHEM., vol. 65, no. 22, 2000, pages 7456 - 67, XP002218886
A. FÜRSTNER ET AL.: "Concise total synthesis of epothilone A and C based on alkyne metathesis", CHEM. COMMUN., 2001, pages 1057 - 9, XP002227326
J. MULZER ET AL.: "Total Synthesis of Epothilones B and D", J. ORG. CHEM., vol. 65, no. 22, 2000, pages 7456 - 67, XP002218886
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