Title:
PROTEIN KINASE POLYPEPTIDE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/015383
Kind Code:
A1
Abstract:
The present invention provides a protein kinase polypeptide inhibitor PI-38, having an amino acid sequence of Ser-Gly-Arg-Val-Met-Arg-Gly-Pro-Arg-Ser-Ala. The polypeptide PI-38 can block the interaction between p38MAPK protein and an effector protein thereof and specifically inhibit p38 kinase activity.
Inventors:
ZHAO SHUMIN (CN)
BAO YONGGANG (CN)
SHI SONGCHUAN (CN)
ZHOU FANG (CN)
WILLIAM CAMBPELL (CN)
CARLOS A DEL CARPIO (CN)
BAO YONGGANG (CN)
SHI SONGCHUAN (CN)
ZHOU FANG (CN)
WILLIAM CAMBPELL (CN)
CARLOS A DEL CARPIO (CN)
Application Number:
PCT/CN2018/087098
Publication Date:
January 24, 2019
Filing Date:
May 16, 2018
Export Citation:
Assignee:
BEIJING PEPMAGIC BIOTECH CORP LTD (CN)
International Classes:
C07K7/06; A61K38/08; A61P19/02; A61P29/00; A61P35/00; A61P35/02
Domestic Patent References:
| WO2012062953A1 | 2012-05-18 |
Foreign References:
| CN107556368A | 2018-01-09 | |||
| CN105555796A | 2016-05-04 | |||
| CN105705158A | 2016-06-22 |
Other References:
FU, JING ET AL.: "Inhibition of Inflammation by a p38 MAP Kinase Targeted Cell Permeable Peptide", MEDICINAL CHEMISTRY, vol. 4, no. 6, 31 December 2008 (2008-12-31), pages 597 - 604, XP055566848, Retrieved from the Internet
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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